Long-lasting stress-induced changes in neuronal alternative splicing

ISBN-13: 9783639147162 / Angielski / Miękka / 2009 / 100 str.

Eran Meshorer

Opis

Ample information suggests multileveled relationshipsbetween long-term psychological stress responses andalternative splicing - the process which yieldsdifferent mRNAs from the same gene. However, thenature of these relationships remains unclear. EranMeshorer studied the stress-induced changes inalternative splicing at Hermona Soreqs lab and shedlight on the molecular pathways that lead to suchresponses. Meshorer focused on a particular mRNA -acetylcholinesterase (AChE), which isneuronally-expressed, stress-responsive, and yieldsalternatively spliced products, thus serving as anadequate model for this purpose. The book begins withan introduction covering the general areas of stressresponses, their long-term consequences, themechanism of splicing and alternative splicing,neuritic translocation of mRNAs and highlights theAChE gene and its protein products as putativemediators of such long-term consequences. The resultssection depicts 3 works describing 3 and 5alternative splicing of AChE and a potential mediatorof the stress-induced responses. Finally, the bookends with a discussion on the consequences of suchresponses, linking stress responses with aging.

O autorze

Eran Meshorer obtained his PhD from The Hebrew University of
Jerusalem, studying long-term stress responses in the brain. He
did his postdoctoral studies at the NIH, studying chromatin in
embryonic stem cells. The work here was published in Science,
JBC, FASEB J and Mol Psychiatry, the latter receiving the Lilly
Award for the best paper of 2005.