Liver Metastasis: Basic Aspects, Detection and Management

ISBN-13: 9789400960534 / Angielski / Miękka / 2012 / 383 str.

Cornelis J. H. Van De Velde; Paul H. Sugarbaker

Opis

B. CADY Hepatic met, ' tasl S present one of the major therapeutic challenges of cancer patien: management, for it is the destruction of vital organ function that makes cancer fatal, not local tumor growth. The process of tumor cell dislodgement from the primary cancer, their spread through the lymphatic and hematogenous channels, their lodgement in distant sites, and their subsequent progressive growth tax our comprehension a'ld i. -ustrate our therapies. The proceedings of this International Con, t ss on Hepatic Metastasis address these aspects of metastases to t: '. >2 _ . ver, and predominatly focus on metastatic colon cancer because of t . s frequency, its prominent hepatic only pattern of spread, and enticing preliminary data about prevention and control of small sub . '(ts of the afflicted population. Predictably, the "false technologies" of Dr. Lewis Thomas that involve surgical, radiotherapeutic and chemo therapeutic attack on these metastases after elaborate diagnostic studies take precedence because of the clinical imperatives of sick patients. This is displayed in the preponderance of papers and in terest in various diagnostic scanning techniques by means of radio isotopes, radiographically useful dyes, biochemical markers, interest in developing accurate staging systems to categorize patients for therapeutic comparisons, and interest in elaborate, and expensive, technology to increase the effectiveness of chemotherap utic agents that are of limited benefit with simple intravenous administration. Behind this clinical enthusiasm, however, lies the research to develop the "true technology," in Thomas' words, that will prevent such clinical catastrophies as hepatic metastases.

Spis treści

Basic Aspects of Liver Metastasis.- 1. Invasion of the Liver by Tumor Cells.- 2. The Role of Cell Surface Determinants in Large Cell Lymphoma Metastasis to Liver.- 3. Interrelation of Animal Tumor Models to the Clinical Problem of the Treatment of Hepatic Metastases.- 4. Natural History of Liver Metastases.- 5. Methods for Prevention of Metastases in the Perioperative Phase.- Diagnosis and Staging of Liver Metastases.- 6. The Detection of Liver Metastases by Laboratory Tests.- 7. Radionuclide Imaging for the Detection of Liver Metastases.- 8. Liver Metastasis: The Value of Diagnostic Ultrasound.- 9. EOE-13 and other Contrast Agents for Computed Tomography of the Liver.- 10. Nuclear Magnetic Resonance Imaging of the Liver: Current Status and Future Possibilities.- 11. Radiolabeled Antibodies for the Detection of Cancer: New Approaches to Improve the Sensitivity and Specificity of Immunoscintigraphy.- 12. Peritoneoscopy in the Diagnosis of Liver Metastases.- 13. Histopathological and Cytopathological Aspects of Focal Liver Lesions.- 14. Screening for Liver Metastasis in Daily Practice.- 15. The Necessity for Staging Liver Metastases and Standardizing Treatment-Response Criteria. The Case of Secondaries of Colo-Rectal Origin.- Treatment of Liver Metastases.- 16. Management of Hepatic Metastases: A General Overview.- 17. Adjuvant Chemotherapy for Colo-Rectal Cancer.- 18. Surgical Therapy of Hepatic Metastases.- 19. Radiotherapy in the Treatment of Liver Metastases.- 20. Radiological Intervention Techniques in the Percutaneous Treatment of Liver Metastases.- 21. Intra-Arterial Infusion of Cytotoxic Drugs for the Treatment of Liver Metastases.- New Treatment Modalities.- 22. Intraperitoneal Chemotherapy. A Possible Role in the Treatment of Hepatic Metastases.- 23. The Infusaid Pump and Hepatic Regional Chemotherapy.- 24. Receptor-Mediated Endocytosis by Normal and Proliferating Hepatocytes.- 25. Isolated Regional Liver Perfusion in the Treatment of Hepatic Metastases.- 26. The Use of Microspheres in the Treatment of Liver Metastases.- Surgical Techniques in the Management of Hepatic Metastases.- 27. Techniques of Hepatic Surgery for Metastatic Cancer.- 28. Technique of Hepatic Infusion Chemotherapy.- 29. The Isolated Liver Perfusion Technique for High-Dose Chemotherapy of Metastases from Colo-Rectal Cancer. Two years ’Clinical Experience.- 30. Methodology in the Clinical Study of Hepatic Metastases.- Index of Subjects.