Lipids in Health and Disease

ISBN-13: 9781402088308 / Angielski / Twarda / 2008 / 598 str.

Peter J. Quinn; Xiaoyuan Wang

Opis

Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.

Spis treści

Preface. Contributors. Contributors. Part 1: Fatty Acids. 1. Transcriptional Regulation of Hepatic Fatty Acid Metabolism, Hervé Guillou et al.; 2. Modulation of Protein Function by Isoketals and Levuglandins, Sean S. Davies. 3. Signalling Pathways Controlling Fatty Acid Desaturation, María Cecilia Mansilla et al.; 4. Fatty Acid Hydrolase: A Gate-keeper of the Endocannaboid System, Filomena Fezza et al.; 5. Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids, Jing X. Kang et al.; 6. Eicosenoids in Tumor Progression and Metastasis, Sriram Krishnamoorthy et al.; 7. Fatty Acid Synthase Activity in Tumor Cells, Joy L. Little et al.; Part 2: Phospholipids. 8. Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders, Mikhail Bogdanov et at.; 9. Altered Lipid Metabolism in Brain Injury and Disorders, Rao Muralikrishna Adibhatla et al.; 10. Lysophospholipid activation of G-Protein-coupled receptors, Tetsuji Mutoh et al.; 11. Phospholipid-mediated Signaling and Heart Disease, Paramjit S. Tappia et al.; 12. The Role of Phospholipid Oxidation Products in Inflammatory and Autoimmune Diseases. Evidence from Animal Models and in Humans, Norbert Leitinger. 13. Mediation of Apoptosis by Oxidized Phospholipids, Gilbert O. Fruhwirth et al.; Part 3: Sphingolipids. 14. Regulation of Lipid Metabolism by Sphingolipids, Tilla S. Worgall. 15. Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis, Natasha C. Lucki. 16. Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics, Sahar A. Saddoughi et al.; 17. Glycosphingolipid Disorders of the Brain, Stephanie D. Boomkamp et al.; 18. Role of Neutral Sphingomyelinases in Aging and Inflammation, Mariana Nikolova-Karakashian et al.; 19. Sphingolipid Metabolizing Enzymes as Novel Therapeutic Targets, Andreas Billich et al.; 20. Ceramide-enriched Membrane Domains in Infectious Biology and Development, Katrin Anne Becker et al.; Part 4:Lipidomics. 21. MALDI-TOF MS Analysis of Lipids from Cells, Tissues and Body Fluids, Beate Fuchs et al.; 22. Lipidomics in Diagnosis of Lipidoses, Claude Wolf and Peter J. Quinn.