Lipid Signaling in Human Diseases

ISBN-13: 9783030336707 / Angielski / Miękka / 2021 / 336 str.

Julian Gomez-Cambronero; Michael A. Frohman

Spis treści

Part 1. New Roles for Sphingolipid Signaling and Cell Function.- 1. Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.- 2. Exploring the Therapeutic Landscape of Sphingomyelinases.- 3. Sphingosine kinases as druggable targets.- Part 2. Phospholipase D and Mitogen Phosphatidic Acid in Human Disease.- 4. Prospects for PLD inhibition in cancer and thrombotic disease.- 5. Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer.- 6. Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease.- Part 3. Lipid Kinases and Novel Regulatory Pathways.- 7. Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.- 8. Functions of Nuclear Polyphosphoinositides.- Part 4. Bioactive Lipids in Health and Disease.- 9. Platelet-Activating Factor as an Effector for Environmental Stressors.- 10. Phospholipase D and Choline Metabolism.- Part 5- Lipids and Membrane Microdomains.- 11. Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology.- 12. Lipids and Membrane Microdomains: The Glycerolipid and Alkylphosphocholine Class of Cancer Chemotherapeutic Drugs.- Part 6. Nuclear Trafficking of Lipids.- 13. Inositide-Dependent Nuclear Signalling in Health and Disease.- 14. Lipids in Exosome Biology.