Leptin and Leptin Antagonists

ISBN-13: 9781587063206 / Angielski / Twarda / 2009 / 184 str.

Prof Arieh Gertler

Opis

The discovery of leptin, the obese (ob) gene product which is not expressed as a functional protein in ob/ob mice, focused the scientific community’s attention on its role as an anorexic hormone involved in the negative regulation of food intake

Spis treści

Part I: Molecular Aspects of Leptin Action 1. Leptin Sign al Transduction—A 2009 Update . 2. Insights in the Activated L R C om p lex and the Rational Design of Antagonists 3. Study of Leptin: Leptin Receptor Interaction by F R E T and B R E T Part II: Leptin Involvement in Physiological and Pathological Processes4. Is Leptin a Pro- or Anti-Apoptotic Agent? 5. Leptin Action s in the Gastrointestinal Tract 6. Leptin as a Novel Marker in Breast and Colorectal Cancer 7. The Role of Leptin in Cardiac Physiology and Pathophysiology 8. The Role of Leptin in Bone Development and Growth 9. Involvement of Leptin in Arterial Hypertension 10. Involvement of Leptin in the Indometrial Function 11. The Use of Leptin for the Treatment of Lipodystrophy 12. Use of Anti-Leptin or Anti-Leptin Receptor Antibodies as B lockers of Immune Response 13. Use of Leptin Antagonists as Anti-Inflammatory and Anti-Fibrotic Reagents 14. The Role of Leptin during Early Life in Imprinting Later Metabolic Reponse

O autorze

Gertler, Prof. Arieh