Lectins and Glycoconjugates in Oncology

ISBN-13: 9783642736643 / Angielski / Miękka / 2011 / 224 str.

Hans-Joachim Gabius; Gerd A. Nagel

Opis

Cellular glycoconjugates and their specific receptors, e.g. lectins, form a recognitive and informative transfer system that justifies special scientific and clinical attention. In various contributions reviewing the initiation and recent progress in this rapidly developing field advances in clinical oncology are discussed with regard to basic sciences as well as their application in clinical sciences. The approaches comprise reports from diverse fields such as biochemistry, cell biology, pathology and clinical oncology, addressing questions of how tumors grow and spread, and leading to the improvement of clinical management and tumor diagnosis.

Spis treści

Sialic Acids as Regulators of Molecular and Cellular Interactions.- Endogenous Lectins of Myeloid and Tumor Cells: Characterization and Biological Implications.- Love to Lectins: Personal History and Priority Hysterics.- Gangliosides in Recognitive Cell Interactions and Carbohydrate-Mediated Biosignalling.- Tumor Imaging: Role of the Target Antigen.- Cell Surface Glycoconjugates Associated with Malignancy/ Metastasis of RAW117 Lymphoma Cells.- Alterations in Cell Surface Carbohydrates Affecting Invasion in vitro.- The Effect of Chemical Deglycosylation of Ricin A-Chain on the Therapeutic Potential of Ricin A-Chain Immunotoxins.- Prospects for the Use of Immunotoxins against Solid Tumour Metastases: Studies in a Syngeneic Rat Model System.- Detection of Endogenous Sugar Binding Proteins in Malignant Tumors Especially in Human Breast Cancer.- Histomorphological Characterization of Carbohydrate-Binding Proteins in Human Lung Cancer.- Endogenous Carbohydrate-Binding Proteins in Neuro-Oncology.- Detection of Receptors for Sulfated Polysaccharides in the Microvasculature of Human Cerebral Tissues and Brain Tumours by Use of Biotinylated Probes.- Receptors for Polysaccharides and Neoglycoproteins in Neoplastic and Inflammatory Intestinal Tissue.- Soluble Lectins and Endothelial Cell Growth Factors.- Loss of Contact-Dependent Inhibition of Growth in Chemically Transformed Fibroblasts.- Immunomodulatory Effects by Mistletoe Lectin.- Immunomodulation by Endogenous ß-Galactoside-Specific Lectins.- The Role of Lectins and Glycoconjugates in Cellular Slime Mold Adhesion.

O autorze

Hans-Joachim Gabius obtained his Ph.D. in 1982 at the Max-Planck-Institute for Experimental Medicine in Göttingen. After doing post-doctoral research from 1984-1985 in the group of S. H. Barondes at the UC San Diego, he was appointed first as assistant professor for biochemistry at the Max-Planck-Institute for Experimental Medicine in Göttingen (1987) and then as associate professor for pharmaceutical chemistry atthe University of Marburg (1991). Since 1993 he is heading the Institute for Physiological Chemistry, Faculty of Veterinary Medicine at the University of Munich. Prof. Gabius received numerous research awards including the Otto-Hahn-Medal (1983), the Award of the Dr. Carl-Duisberg-Foundation (1988) and the Award of the Paul-Martini-Foundation (1990). His research interests are focused on chemical, biophysical and biochemical analysis of protein - carbohydrate interactions with biomedical relevance, such as the development of glycoscientific strategies for tumor diagnosis and therapy and the elucidation of functions of mammalian lectins. His research led to a prominent placement in the ISI ranking of highly cited papers in 1998.