Kindling 4

ISBN-13: 9781468457988 / Angielski / Miękka / 2012 / 490 str.

Juhn A. Wada; Juhn A. Wada

Opis

This is the proceedings of the fourth in a series of inter- national gatherings on kindling held on the University of British Columbia campus, June 15-17, 1989. Since the last gath- ering in 1985, kindling continues to attract an ever-increasing number of investigators as reflected by the phenomenal increase in the number of kindling-related research reports. No other acute or chronic model has been exploited so extensively using electrophysiological, pharmacological, biochemical and behav- ioural approaches involving a variety of brain sites and ani- mal species. The continuing search, during the past few years, for the mechanism underlying the enduring change induced by kindling is beginning to shed some light on aspects of its molecular basis and to suggest the future direction of research. The late Graham Goddard, the original kindler, would have been delighted with this development. We were all shocked and saddened by his tragic death, but his spirit is very much alive among all of us who gathered together to share new information and collectively reassess the present state of knowledge at this symposium. I must say that we miss him very, very much. We know he is happy in his heaven knowing that he accomplished more in a short lifetime than most and that his love for mankind, and life's challenges, remain as a legacy, and goal, for us all.

Spis treści

Kindling as a Model of Long-Lasting Plasticity: New Perspectives in the Search for Molecular Mechanisms.- Spontaneous Electrographic Seizures in the Hippocampal Slice: an in vitro Model for the Study of the Transition from Interictal Bursting to Ictal Activity.- Is the Pyriform Cortex Important for Limbic Kindling?.- Metabolic Maps of Kindling: A Sequential Double-Label Deoxyglucose Study.- Seizure Mechanisms in the Piriform Cortex.- Double-label Quantitative Autoradiographic Studies of Anaerobic Glucose Metabolism in Limbic Seizures.- Alterations of Synaptic Ultrastructure Induced by Hippocampal Kindling.- Forebrain and Brainstem Mechanisms Governing Kindled Seizure Development: A Hypothesis.- Genetic Contributions to Kindling: An Experimental Approach.- The GABA Hypothesis of Kindling.- Noradrenaline and Kindling Revisited.- Mechanisms of Kindling in Developing Animals.- The Kindling Process and Vulnerability to Status Epilepticus.- Frequency- and Time-Domain EEG Topographic Analysis of the Amygdala Kindling Evolution in the Cat.- N-Methyl-D-Aspartate (NMDA) Receptors and the Kindling Model.- Does Electrical and Excitatory Amino Acid Kindling Share a Common Neurobiological Mechanism?.- Involvement of Excitatory Amino Acids in the Mechanisms of Kindling.- Kindling and Excitatory Amino Acids.- Effect of Selective Lesions Within the Substantia Nigra on the Anticonvulsant Effect of Antiepileptic Drugs in Fully-Kindled Rats.- Pharmacological and Toxicological Evaluation of Potential Anti-Epileptic Drugs in the Kindling Model of Epilepsy.- Contingent Tolerance to the Anticonvulsant Effects of Drugs on Kindled Convulsions.- Can Kindling-Induced Sleep Pathology be Corrected by Phenobarbital?.- Basic Mechanisms Underlying Seizure-Prone and Seizure-Resistant Sleep and Awakening States in Feline Kindled and Penicillin Epilepsy.- Kindling, Anxiety and Limbic Epilepsy: Human and Animal Perspectives.- Pharmacological Dissociation Between the Mechanisms of Kindling and Long-Term Potentiation by APV and Urethane Anesthesia.- Amygdala Versus Local Anesthetic Kindling: Differential Anatomy, Pharmacology and Clinical Implications.- The Role of the Hippocampal System in the Epileptic Transference Phenomenon of Kindling.- Erosion of Kindled Epileptogenesis and Kindling-Induced Long-Term Seizure Suppressive Effect in Primates.- Claustrum and Amygdaloid Kindling.- Midline Thalamus and Amygdaloid Kindling.- Adenosine Involvement in Kindled Seizures.- Dr. Calvo’s Presentation and Discussion.- General Discussion.