Keynotes in Organic Chemistry

ISBN-13: 9781119999140 / Angielski / Miękka / 2013 / 304 str.

Andrew F. Parsons

Opis

This concise and accessible book provides organic chemistry notes for students studying chemistry and related courses at undergraduate level, covering core organic chemistry in a format ideal for learning and rapid revision. The material is organised so that fundamental concepts are introduced early, then built on to provide an overview of the essentials of functional group chemistry and reactivity, leading the student to a solid understanding of the basics of organic chemistry. Graphical presentation of information is central to the book, to facilitate the rapid assimilation, understanding and recall of critical concepts, facts and definitions. Students wanting a comprehensive and accessible overview of organic chemistry to build the necessary foundations for a more detailed study will find this book an ideal source of the information they require. In addition, the structured presentation, highly graphical nature of the text and practice problems with outline answers will provide an invaluable framework and aid to revision for students preparing for examinations. Keynotes in Organic Chemistry is also a handy desk reference for advanced students, postgraduates and researchers. For this second edition the text has been completely revised and updated. Colour has been introduced to clarify aspects of reaction mechanisms, and new margin notes to emphasise the links between different topics. The number of problems have been doubled to approximately 100, and includes spectra interpretation problems. Each chapter now starts with diagrams to illustrate the key points, and ends with a list of key reactions and a worked example.

Now in an expanded second edition, this accessible book provides organic chemistry notes for students studying chemistry and related courses at the undergraduate level. It covers core organic chemistry in a format ideal for learning and rapid review. The material is organized to introduce fundamental concepts early.

Recenzje

I recommend instructors delivering undergraduate organic chemistry consider promoting this textbook to their students as a keynote revision guide.   (Appl. Organometal. Chem, 17 November 2014)

Spis treści

Preface xi

1 Structure and bonding 1

1.1 Ionic versus covalent bonds 1

1.2 The octet rule 2

1.3 Formal charge 2

1.4 Sigma and pi bonds 3

1.5 Hybridisation 4

1.6 Inductive effects, hyperconjugation and mesomeric effects 6

1.7 Acidity and basicity 9

2 Functional groups, nomenclature and drawing organic compounds 21

2.1 Functional groups 21

2.2 Alkyl and aryl groups 22

2.3 Alkyl substitution 23

2.4 Naming carbon chains 23

2.5 Drawing organic structures 27

3 Stereochemistry 31

3.1 Isomerism 31

3.2 Conformational isomers 32

3.3 Configurational isomers 37

4 Reactivity and mechanism 49

4.1 Reactive intermediates: ions versus radicals 49

4.2 Nucleophiles and electrophiles 51

4.3 Carbocations, carbanions and carbon radicals 53

4.4 Steric effects 55

4.5 Oxidation levels 55

4.6 General types of reaction 56

4.7 Ions versus radicals 59

4.8 Reaction selectivity 60

4.9 Reaction thermodynamics and kinetics 60

4.10 Orbital overlap and energy 65

4.11 Guidelines for drawing reaction mechanisms 67

5 Halogenoalkanes 73

5.1 Structure 73

5.2 Preparation 74

5.3 Reactions 78

6 Alkenes and alkynes 95

6.1 Structure 95

6.2 Alkenes 97

6.3 Alkynes 110

7 Benzenes 117

7.1 Structure 117

7.2 Reactions 119

7.3 Reactivity of substituted benzenes 123

7.4 Nucleophilic aromatic substitution (the SNAr mechanism) 127

7.5 The formation of benzyne 128

7.6 Transformation of side chains 129

7.7 Reduction of the benzene ring 132

7.8 The synthesis of substituted benzenes 132

7.9 Electrophilic substitution of naphthalene 135

7.10 Electrophilic substitution of pyridine 135

7.11 Electrophilic substitution of pyrrole, furan and thiophene 136

8 Carbonyl compounds: aldehydes and ketones 139

8.1 Structure 139

8.2 Reactivity 140

8.3 Nucleophilic addition reactions 142

8.4 a–Substitution reactions 156

8.5 Carbonyl–carbonyl condensation reactions 160

9 Carbonyl compounds: carboxylic acids and derivatives 167

9.1 Structure 167

9.2 Reactivity 168

9.3 Nucleophilic acyl substitution reactions 168

9.4 Nucleophilic substitution reactions of carboxylic acids 170

9.5 Nucleophilic substitution reactions of acid chlorides 171

9.6 Nucleophilic substitution reactions of acid anhydrides 172

9.7 Nucleophilic substitution reactions of esters 173

9.8 Nucleophilic substitution and reduction reactions of amides 175

9.9 Nucleophilic addition reactions of nitriles 176

9.10 a–Substitution reactions of carboxylic acids 178

9.11 Carbonyl–carbonyl condensation reactions 178

10 Spectroscopy 185

10.1 Mass spectrometry (MS) 185

10.2 The electromagnetic spectrum 189

10.3 Ultraviolet (UV) spectroscopy 190

10.4 Infrared (IR) spectroscopy 192

10.5 Nuclear magnetic resonance (NMR) spectroscopy 194

11 Natural products and synthetic polymers 207

11.1 Carbohydrates 207

11.2 Lipids 209

11.3 Amino acids, peptides and proteins 211

11.4 Nucleic acids 213

11.5 Synthetic polymers 214

Worked example 218

Problems 219

Appendix 1: Bond dissociation enthalpies 221

Appendix 2: Bond lengths 223

Appendix 3: Approximate pKa values (relative to water) 225

Appendix 4: Useful abbreviations 227

Appendix 5: Infrared absorptions 229

Appendix 6: Approximate NMR chemical shifts 231

Appendix 7: Reaction summaries 235

Appendix 8: Glossary 241

Further reading 249

Outline answers 251

Index 277

Blurb

This concise and accessible textbook provides notes for students studying chemistry and related courses at undergraduate level, covering core organic chemistry in a format ideal for learning and rapid revision. With an emphasis on pictorial presentation, the material, is organised to provide an overview of the essentials of functional group chemistry and reactivity, leading the student to a solid understanding of the basics of organic chemistry. 

This revised and updated second edition of Keynotes in Organic Chemistryincludes:

• new margin notes to emphasise links between different topics,
• colour diagrams to clarify aspects of reaction mechanisms and illustrate key points, and
• a new keyword glossary.

In addition, the structured presentation provides an invaluable framework to facilitate the rapid learning, understanding and recall of critical concepts, facts and definitions. Worked examples and questions are included at the end of each chapter to test the reader s understanding.

Reviews of the First Edition

"...this text provides an outline of what should be known and understood, including fundamental concepts and mechanisms."
Journal of Chemical Education, 2004

Despite the book′s small size, each chapter is thorough, with coverage of all important reactions found at first–year level... ideal for the first–year student wishing to revise... and priced and designed appropriately."
The Times Higher Education Supplement, 2004