Ion Channels as Therapeutic Targets, Part a: Volume 103

ISBN-13: 9780128047941 / Angielski / Twarda / 2016 / 402 str.

Rossen Donev

Opis

Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

• Provides cutting-edge developments in protein chemistry and structural biology
• Discusses the use of ion channels as therapeutic targets
• Chapters are written by authorities in their field
• Targeted to a wide audience of researchers, specialists, and students

Spis treści

1. Proteostasis Maintenance of Cys-Loop ReceptorsYan-Lin Fu, Ya-Juan Wang and Ting-Wei Mu2. Harnessing the Flow of Excitation: TRP, Voltage-Gated Na+, and Voltage-Gated Ca2+ Channels in Contemporary MedicineRoman V. Frolov and Matti Weckström3. Ion Channels in Neurological DisordersPravir Kumar, Dhiraj Kumar, Saurabh Kumar Jha, Niraj Kumar Jha and Rashmi K. Ambasta4. Acid Sensing Ion Channels as Potential Pharmacological Targets in Peripheral and Central Nervous System DiseasesBeatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu and Mihai Radu5. Glutamatergic NMDA Receptor as Therapeutic Target for DepressionGislaine Z. Réus, Helena M. Abelaira, Talita Tuon, Stephanie E. Titus, Zuleide M. Ignácio, Ana Lúcia S. Rodrigues and João Quevedo6. AMPA Receptors as Therapeutic Targets for Neurological DisordersKevin Lee, Lucy Goodman, Chantelle Fourie, Susan Schenk, Beulah Leitch and Johanna M. Montgomery7. pH-Sensitive K+ Currents and Properties of K2P Channels in Murine Hippocampal AstrocytesJohannes Weller, Christian Steinhäuser and Gerald Seifert8. SUMOylation and Potassium Channels: Links to Epilepsy and Sudden DeathHongmei Wu, Xu Chen, Jinke Cheng and Yitao Qi

O autorze

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.