Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

ISBN-13: 9780128038147 / Angielski / Miękka / 2017 / 406 str.

Kenneth Kam Lo

Opis

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents.

• Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas
• Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells
• Foscuses on the fundamentals and their potential therapeutic and diagnostic applications
• Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents

Spis treści

1. Luminescent Zinc Complexes as Bioprobes for Imaging Molecular Events in Live Cells 2. Cellular Uptake and Sensing Capability of Transition Metal Peptide Conjugates 3. Luminescent Rhenium(I) and Iridium(III) Complexes for Intracellular Labeling, Sensing, and Photodynamic Therapy Applications 4. Organoruthenium(II)-Arene Complexes: Structural Building Blocks for Anticancer Drug Discovery 5. Medicinal Chemistry of Metal N-Heterocyclic Carbene (NHC) Complexes 6. Metal Complexes as Delivery Systems for CO, NO, and H₂S to Explore the Signaling Network of Small-Molecule Messengers 7. Antimicrobial Metallodrugs 8. Carbon Nanotubes and Related Nanohybrids Incorporating Inorganic Transition Metal Compounds and Radioactive Species as Synthetic Scaffolds for Nanomedicine Design 9. Immobilized Metal Affinity Chromatography (IMAC) for Metalloproteomics and Phosphoproteomics 10. The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions

O autorze

Professor Kenneth Lo obtained his PhD degree in 1997 at The University of Hong Kong. His PhD work centered on the design of luminescent transition metal complexes as DNA and metal-ion probes; and the photophysical and photochemical studies of luminescent polynuclear coinage metal chalcogenide complexes. From 1997 to 1999, he worked as a Croucher Foundation Postdoctoral Research Fellow in the Inorganic Chemistry Laboratory, University of Oxford. He carried out research work on genetic engineering and electrochemistry of cytochrome P450cam and putidaredoxin. Professor Lo joined the Department of Biology and Chemistry of City University of Hong Kong as Assistant Professor in 1999 and became Associate Professor (Scale B) in 2003, Associate Professor (Scale A) in 2007, and Professor in 2011. Professor Lo's research interest is the utilization of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes, with a focus on the development of intracellular sensors, photoactive labels, and bioimaging reagents. He received The APA Prize for Young Scientist from the Asian and Oceanian Photochemistry Association in 2005 and the Distinguished Lectureship Award from the Chemical Society of Japan in 2011. He is currently on the Editorial Advisory Board of Inorganic Chemistry and is an Associate Editor of RSC Advances. He isone of the Vice Chairs of the Gordon Research Conference Metals in Medicine 2016. He was awarded a Croucher Senior Research Fellowship (2015 - 2016) from the Croucher Foundation.