Inhibitors of the Ras Superfamily G-Proteins, Part a: Volume 33

ISBN-13: 9780124167490 / Angielski / Twarda / 2013 / 364 str.

Fuyuhiko Tamanoi

Opis

This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

• Contributions from leading authorities
• Informs and updates on all the latest developments in the field

Spis treści

1. The Ras superfamily G-proteins
   Fuyuhiko Tamanoi
2. NMR Study to Identify a Ligand-Binding Pocket in Ras
   Till Maurer and Weiru Wang
3. The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules
   Christian W. Johnson and Carla Mattos
4. State 1(T) Inhibitors of Activated Ras
   Hans Robert Kalbitzer and Michael Spoerner
5. Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface 
   Alessandro Di Domizio and Francesco Peri
6. Development of EHop-016, a Small Molecule Inhibitor of Rac
   Suranganie Dharmawardhane
7. Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors
   Susanne Schmidt and Anne Debant
8. Targeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways
   Anne Blangy and Philippe Fort
9. Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase
   Dominico Vigil and Channing J. Der
10. A Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF Interaction
    Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis
11. Inhibitors of K-Ras Plasma Membrane Localization
    Kwang-jin Cho, Dharini van der Hoeven and John F. Hancock
12. Ras Chaperons: New Targets for Cancer and Immunotherapy
    Yoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor
    

O autorze

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.