Inflammation and Demyelination in the Central Nervous System: International Congress of Neuropathology, Vienna, September 5-10, 1982

ISBN-13: 9783540124207 / Angielski / Miękka / 1983 / 94 str.

B. H. Waksman; T. Yonezawa; H. Lassmann

Opis

The present report, compares two murine models of virus induced chronic relapsing demyelination. MHV-induced demyelination in the BALB/c mouse results from the direct virus mediated cytolysis of oligodendrocytes. Extensive remyelination by oligodendrocytes is noted. Recurrent demyel- ination occurs in small areas. Infectious virus persists and 34 Fig. 2: Demyelination in SJL/J mice infected with TMEV. A) Multifocal areas of perivascular demyelination in the spinal cord (110 days post infection). Para- phenylene diamine stain. X 250. B) Perivascular inflammatory infiltration within the white matter of the spinal cord (22 days post infec- tion). Paraphenylene diamine stain. X600. C) Localization of TMEV associated antigen in the cytoplasm of oligodendrocytes (45 days post infec- tion). Vibratome section stained with the peroxidase-anti peroxidase technique. X 400. D) Immunoperoxidase staining of viral antigen within inner and outer loops of an oligodendrocyte (45 days post infectin) X 60,000. E) Longitudinal section showing viral antigen within Schmidt-Lanterman incisures (80 days post infection). X 49,000. viral antigens are localized within oligodendrocytes and their processes. TMEV-induced demyelination in SJL/J mice is asso- ciated with perivascular inflammatory infilrates and is dimin- ished by immunosuppressive measures. Remyelination by oligo- dendrocytes is delayed and incomplete. Chronic demyelination is widespread and associated with perivascular inflammatory infiltrates. The virus persists and viral antigen is local- ized within oligodendrocytes.

Spis treści

Immunologic Models of Acute and Chronic Inflammation.- Abnormalities of Immunocyte Function in Multiple Sclerosis.- Etiology and Pathogenesis of Monophasic and Relapsing Inflammatory Demyelination — Human and Experimental.- Virologic Models of Chronic Relapsing Demyelinating Disease.- Murine Experimental Allergic Encephalomyelitis.- Circulating Myelinotoxic Factors in Human and Experimental Demyelinative Disease.- Analysis of Humoral and Cellular Events and the Role of Lipid Haptens During CNS Demyelination.- Neurochemical and Model Membrane Studies in Demyelinating Diseases.