Inflammasomes: Clinical and Therapeutic Implications

ISBN-13: 9783319893891 / Angielski / Twarda / 2018 / 400 str.

Mario D. Cordero; Elisabet Alcocer-Gomez

Opis

This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications.

Spis treści

Chapter 1: Bases of the inflammasomes in the clinical practice. A brief introduction.- Chapter 2: The Inflammasomes in Cardiovascular Disease.- Chapter 3: Inflammasomes in CNS diseases.- Chapter 4: Lung Diseases.- Chapter 5: Traumatic Injury.- Chapter 6: Inflammasome in the pathogenesis of pulmonary diseases.- Chapter 7: Inflammasome and Oral Diseases.- Chapter 8: Inflammasomes in the kidney.- Chapter 9: Pro-inflammatory actions of red blood cell-derived DAMPs.- Chapter 10: Role of Inflammasomes in the Development of Gastrointestinal Diseases.- Chapter 11: Inflammasomes in bone diseases.- Chapter 12: Inflammasome in Cancer.- Chapter 13: Aging and the inflammasomes.- Chapter 14: Genetics of inflammasome.- Chapter 15: Therapeutic implications of the inflammasomes.

O autorze

Mario D Cordero is Research Associate at the University of Sevilla. He studies the role of inflammasomes in metabolic and cardiovascular diseases, with special attention on the implication of NLRP3 in age-associated diseases. He is also involved in the evaluation of inflammasome inhibitors in rare diseases.

Dr Cordero is one of the editors of volume no. 107 on AMP-activated protein kinases in the same series.  

Elísabet Alcocer-Gómez is Research Associate at the University of Sevilla. Her scientific interest is the implication of inflammasome complexes in psychiatric diseases and the effect of psychiatric drugs on the inhibition or induction of inflammasome activation. 

Blurb

This volume focuses on the role of inflammasomes in a variety of diseases and their therapeutic options. It gives an overview of the current studies elucidating the molecular implications in the medical and  clinical contexts. It covers inflammasomes as potential therapeutic targets and evaluates the benefits of inflammasome inhibitors.