In Vitro Neurotoxicology: Principles and Challenges

ISBN-13: 9781617373237 / Angielski / Miękka / 2010 / 331 str.

Evelyn Tiffany-Castiglioni

Opis

Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.

Recenzje

"This book covers a wide range of topics, starting with a nice overview of the field of neurotoxicology. Moving on to the meat of the material, the effects of toxins on neural development, function, and degeneration are examined, using well studied neurotoxicants as examples. A thorough list of articles as well as an annotated reading list are valuable additions, making the book an excellent reference. This is a valuable reference for anyone studying the advances in neurotoxicology. It is concise and easy to comprehend, without sacrificing quality in the process. It is written by leaders in the field, ensuring the information is relevant and up-to-date."-Doody's Health Sciences Book Review Journal

"This is a useful book that updates new an improved in vitro methods to help further understanding neurotoxicology. The information presented is exciting, the methods proposed are often innovative, and readers will find a challenging glimpse into the future contributions their own research efforts can generate. Neurotoxicologists will find studying this volume rewarding and inspiring." - Vet Human Toxicol

"...a helpful and up to date book..." - BTS Newsletter

Spis treści

In Vitro Neurotoxicology: Introduction to Concepts Evelyn Tiffany-Castiglioni Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment Marion Ehrich and David C. Dorman Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics William H. Hanneman, Melvin E. Andersen, Marie E. Legare, Christine T. French, Tami S. McMullin, Carolyn Broccardo, and Ruth E. Billings In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis Gerald J. Audesirk and Ronald B. Tjalkens Role of Apoptosis in Neurotoxicology Lori D. White, Sid Hunter, Michael W. Miller, Marion Ehrich, and Stanley Barone, Jr. Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants: Enzyme Pathways in Neurons and Astroglia Michael Aschner and Ursula Sonnewald Cell-Type-Specific Responses of the Nervous System to Lead Evelyn Tiffany-Castiglioni and Yongchang Qian Effects of Toxicants on Neural Differentiation Stanley Barone, Jr., Prasada R. S. Kodavanti, and William R. Mundy Impairment of Synaptic Function by Exposure to Lead Stephen M. Lasley and Mary E. Gilbert Aggregating Brain Cell Cultures for Neurotoxicological Studies Marie-Gabrielle Zurich, Florianne Monnet-Tschudi, Lucio G. Costa, Benoît Schilter, and Paul Honegger Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors W. Les Dees, Jill K. Hiney, Robert K. Dearth, and Vinod K. Srivastava Establishing In Vitro Models to Study Endogenous Neurotoxicants Heather D. Durham Appendix: Annotated Reading List Evelyn Tiffany-Castiglioni, Lucio G. Costa, Marion Ehrich, William R. Mundy, Gerald J. Audesirk, Michael Aschner, Prasada R. S. Kodavanti, and Stephen M. Lasley Index

Blurb

Neurotoxicity assessment with in vitro systems offers not only a means to better understand mechanisms of action of toxicants and decrease reliance on laboratory animals, but also provides a basis for reliable, high throughput screening of new and untested chemicals. In In Vitro Neurotoxicology: Principles and Challenges, well-respected leaders in the field take a fresh look at their own and others' work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. In thematically organized chapters, the authors employ examples comprised of multiple experimental systems and endpoints, and discuss the use of complementary in vivo/in vitro strategies. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well studied both in vivo and in vitro: lead, mercury, organophosphorus insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. Several neurotoxicology topics covered provide insight into neurodevelopmental and neurodegenerative diseases, including the concept of astroglia as depots for lead and other metals in the central nervous system, the elucidation of factors involved in the onset of puberty in females, and the exploration of endogenous proteins as neurotoxicants.
Authoritative and forward-looking, In Vitro Neurotoxicology: Principles and Challenges sets out new concepts and research directions that will facilitate significant improvement in today's methods and systems for in vitro neurotoxicity testing.