In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent

ISBN-13: 9783843371094 / Angielski / Miękka / 2012 / 148 str.

Sanjay Patel; Umesh Shiroya; Anand Patel

Opis

Heterobicyclic oxazolo pyrimidinone are important class of compounds. They may become promising candidates for exploiting more useful therapeutically active molecules. The compounds having oxazolo pyrimidinone moiety are associated with interesting wide spectrum biological activities, such as antibacterial, kinase inhibition, adenosine receptor antagonism, tumour growth inhibition and some show to inhibit the ability of ricin to inactivate the ribosomes etc. The intermediate azlactones are also useful precursors for the synthesis of amino acids, peptides, heterocycles, biosensors and antitumor or antimicrobial compounds. In the present study, it was proposed to synthesize lead molecules of oxazolo pyrimidinone skeleton, apt for binding to the target enzyme, bacterial MurB based on the rational approach and to study their docking simulations using ArgusLab 4.0.1 and AutoDock 4.2 softwares. The synthesized test compounds were then characterized by TLC, melting point determination, UV, IR, 1H-NMR and mass spectral studies and tested for their antibacterial activity and compare with the standard drug.

O autorze

PATEL, SANJAYI have completed M.Pharm (Pharm. Chemistry) from Gujarat Technological University, Gujarat (India). Currently working as a Research Associate Scientist in Piramal Discovery Solutions. I have expertise in Drug designing & also have sound knowledge of Chemistry. My research work is dedicated to my PARENTS.