Immunobiology of Bone Marrow Transplantation: International Seminar of the Institut Für Hämatologie, Gsf, Munich Under the Auspices of the European Co

ISBN-13: 9783540094050 / Angielski / Miękka / 1980 / 432 str.

S. Thierfelder; H. Rodt; H. J. Kolb

Opis

Bone marrow transplantation, the goal which integrates hemato logists, immunologists, geneticists, oncologists and specialists of several other fields, has overcome its state of stagnation in recent years. Clinically as well as experimentally new approaches to old problems and new conclusions from recent findings proliferate: bone marrow transplantation in leukemic remission, bone marrow growth in cell culture, bone marrow manipulation with antisera, bone marrow differentiation in histoincompatible hosts, immuno suppression with partial body irradiation to cite just a few. These and other new developments were discussed by experts from 12 countries in and outside the European Community during an international seminar held on March 8-10, 1979 by the "Institut fur Hamatologie, GSF," under the auspices of the European Communities. The editors thank both the contributors to this symposium, who made it a successful meeting and submitted their manuscripts punctually, and the publishers, who have provided a volume of high quality in good time. They are also grateful for the valuable cooperation from numerous colleagues at the Institut fur Hamato logie."

Spis treści

1 Experimental Bone Marrow Transplantation in Rodents.- Immune Responses and Tolerance to Donor Tissue in Nude Mice Grafted with an Allogeneic Thymus.- Transplantation of Cultured Hemopoietic Stem Cells.- Stromal Mechanisms of Bone Marrow: Cloning in Vitro and Retransplantation in Vivo.- Graft-Versus-Leukemia: Allosensitization of MHC Compatible Donors Induces Antileukemic Reactivity Without Amplification of Antihost Reactivity.- 2 Experimental Bone Marrow Transplantation in Dogs.- Marrow Graft Studies in Dogs.- Collection, Cryopreservation and Transplantation of Blood Stem Cells in the Treatment of Hemopoietic Failure.- Bone Marrow Transplantation in DLA-Haploidentical Canine Littermates — Fractionated Total Body Irradiation (FTBI) and in Vitro Treatment of the Marrow Graft with Anti-T-Cell Globulin (ATCG).- 3 Immunocompetence and Histocompatibility in Bone Marrow Transplantation.- Immunobiology of Minor Histocompatibility Antigens in the Lethal Graft-versus-Host-Reaction Induced in Adult Mice.- The Role of MHC Gene Products in the Development of the T-Cell Repertoire.- T-Cell Mediated Cytotoxic Immune Reactivity of Bone Marrow Reconstituted Chimeric Mice.- Involvement of the HLA System in the Immune Response.- Histocompatibility Testing for Clinical Bone Marrow Transplantation and Prospects for Identification of Donors Other than HLA Genotypically Identical Siblings.- T-Cell Subpopulations After Allogeneic Bone Marrow Transplantation.- Cooperation Between Thymus and Transplanted Precursor Cells During Reconstitution of Immunodeficiencies with Bone Marrow or Fetal Liver Cells.- 4 Suppression of Graft Versus Host Reactions with Antisera Against Cell Surface Markers.- Restitution Potentials of Allogeneically or Xenogeneically Grafted Lymphocyte-free Hemopoietic Stem Cells.- Influence of the Recipient Thymus on the Maturation of T-Lymphocytes in H-2 Different Radiation Chimeras.- Surface Antigens Characterizing Lymphopoietic Stem Cells in Rats.- Bone Marrow Transplantation into Recipients Sensitized Against Donor-type T Cells.- Prevention of Graft Versus Host Reactions and Conditioning of Recipients for Bone Marrow Transplantation in Chickens.- 5 Suppression of Graft Versus Host Reactions with Cyclosporin A.- Use of Cyclosporin A (CsA) in a Rat Model of Allogeneic Marrow Transplantation.- Cyclosporin A in Human Bone Marrow Grafts.- 6 Autologous Bone Marrow Transplantation.- Immunological Studies in Patients Submitted to Autologous Bone Marrow Transplantation.- Autologous Bone Marrow Transplantation. The Influence of Prolonged Cytotoxic Chemotherapy.- Requirements for the Successful Application of Autologous Bone Marrow Transplantation in the Treatment of Selected Malignancies.- The Concept of Antileukemic, Autologous Bone Marrow Transplantation in Acute Lymphoblastic Leukemia.- Autologous Bone Marrow Transplantation in Relapsed Adult Acute Leukemia.- 7 Conditioning of Bone Marrow Recipients.- Mechanisms of Transplantation Tolerance to Allogeneic Bone Marrow Cells Following Total Lymphoid Irradiation (TLI).- Combined Immunosuppression Using Cyclophosphamide Plus Total Lymphoid Irradiation in Preparation for Allogeneic Marrow Transplantation in Humans.- Bone Marrow Grafting in Aplastic Anemia After Conditioning with Cyclophosphamide and Total Body Irradiation with Lung Shielding.- Role of Total Body Irradiation in Conditioning for Bone Marrow Transplantation.- 8 Allogeneic Bone Marrow Transplantation for the Treatment of Leukemia, Aplastic Anemia and Immunodeficiency.- Recent Results in Marrow Transplantation for the Treatment of Aplastic Anemia and Acute Leukemia in Seattle.- Marrow Transplantation in Acute Leukemia Following Busulf an and Cyclophosphamide.- Colony Forming Units in Culture in Childhood Aplastic Anemia.- Split Chimerism in Three Patients Suffering from Severe Combined Immunodeficiency (SCID).- Transplantation of Lymphoid Cells in Patients with Severe Combined Immunodeficiency (SCID).- Y-Chromatin: Method to Study a Take or Rejection After Bone Marrow Transplantation.- 9 Summing up.- Summing up in Perspective.