Il-17, Il-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

ISBN-13: 9783034805216 / Angielski / Twarda / 2012 / 354 str.

Val Rie Quesniaux; Bernhard Ryffel; Franco Padova

Opis

The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.

Spis treści

IL-17A family, receptors, proinflammatory effects and production.- IL-22 and IL-17 overview.- IL-17R family: Structure, signal transduction and function.- Contribution of IL-22 to Th17 responses: repairing and protecting peripheral tissues.- Central role of Th-17 cells in adaptive immune responses.- Regulatory T cells vs Th17: Differentiation of Th17 versus Treg are they mutually exclusive Other sources of IL-17: iNKT cells.- Retinoic acid in mucosal immune regulation.- Critical role of IL-17 in experimental arthritis.- Dual role IL-17A, F and IL-22 in allergic asthma.- Inflammasome - IL-1 - IL-17 response in lung inflammation.- The role of Il-17 in exp autoimmune mycocarditis.- Th17 cells in transplantation: actors or innocent bystanders.- Is IL-17 required to control of tuberculosis IL-17 and mucosal host defense. Role of IL-17 and IL-17 family cytokines on tumor development.- IL-17 and TH17 cells in rheumatoid arthritis and other inflammatory conditions.- Targeting Th17 Cells for therapy of multiple sclerosis.- Involvement of interleukin-17 cytokines in human asthma.- IL-17 and/or IL-22 as potential target(s) for Crohn’s disease.- Role of IL-23, IL-17 and IL-22 in psoriasis.- Contribution of IL-22 to experimental skin inflammation.- Genetic mouse models to investigate IL-17 responses.- IL-17A as a therapeutic target for autoimmune diseases.

Blurb

The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.