Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes

ISBN-13: 9783540767329 / Angielski / Twarda / 2008 / 287 str.

Jan Tachezy

Opis

"Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes" provides a summary of the current knowledge of these organelles which occur in unicellular, often parasitic organisms, including human pathogens. These organelles exhibit a variety of structures and functions. This work describes properties such as protein import, structure, metabolism, adaptation, proteome and their role in drug activation and resistance. Further topics include organelle evolution and biogenesis.

Spis treści

Anaerobic Eukaryotes in Pursuit of Phylogenetic Normality: the Evolution of Hydrogenosomes and Mitosomes.- Protein Import into Hydrogenosomes and Mitosomes.- Structure of the Hydrogenosome.- Hydrogenosomes of Anaerobic Ciliates.- Metabolism of Trichomonad Hydrogenosomes.- Hydrogenosomes of Anaerobic Chytrids: An Alternative Way to Adapt to Anaerobic Environments.- The Proteome of T. vaginalis Hydrogenosomes.- Hydrogenosome: The Site of 5-Nitroimidazole Activation and Resistance.- Mitosomes in Parasitic Protists.- The Mitochondrion-Related Organelle of Cryptosporidium parvum.- Mitochondrial Remnant in Blastocystis.- Possible Mitochondria-Related Organelles in Poorly-Studied “Amitochondriate” Eukaryotes.

Blurb

"Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes" provides a summary of the current knowledge of these organelles, which occur in unicellular, often parasitic organisms, including human pathogens. The distribution of these organelles is broad, but they were detected primarily in an anoxic habitat or nutrient rich intracellular niche that permits life without the efficient energy generating system of typical mitochondria. Their common characteristic is that they lack the aerobic energy conservation system of typical mitochondria and that they are usually the site of the synthesis of iron-sulfur clusters, regarded as the only indispensable function of eukaryotic mitochondria.

These mitochondria-related organelles exhibit a variety of structures and functions. This work describes properties such as protein import, structure, metabolism, adaptation, proteome and their role in drug activation and resistance. Further topics include the evolution and biogenesis of these organelles.