Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution

ISBN-13: 9781466594869 / Angielski / Twarda / 2014 / 259 str.

Raymond C. Valentine; David L. Valentine

Opis

More than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman s famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membrane oxidation introduced in this book. This concept is consistent with recent discoveries showing that mitochondria-targeted antioxidants prevent Huntington s disease, Parkinson s disease, and traumatic brain disease in animal models of neurodegeneration. This book explores a unified theory of aging based on bioenergetics. It covers a variety of topics including an introduction to the science of human aging, the Darwinian selection of membranes enabling longevity, a revised mitochondrial membrane hypothesis of aging, and various mechanisms that protect human mitochondrial membranes, thereby enabling longevity."

Spis treści

Introduction to the Science of Human Aging. Darwinian Selection of Membranes Enabling Longevity. Revised Mitochondrial Membrane Hypothesis of Aging. Many Mechanisms Have Evolved to Protect Human Mitochondrial Membranes, Enabling Longevity.