Human Ipsc-Derived Disease Models for Drug Discovery

ISBN-13: 9783031423482 / Angielski

Markus H. Kuehn; Wei Zhu

Spis treści

Part 1 General considerations.- Human iPS for clinical applications and cellular products.- 3D-printed iPS disease models.- Part 2 CNS iPSC and organoids.- iPS-derived neurons and brain organoids from patients (brain).- iPS-derived RGCs (eye).- iPS-derived glia (brain).- iPSC to model blood-brain barrier endothelial cells.- Part 3 iPSC-derived nociceptive neurons.- IPSC-based peripheral nerve modeling.- Part 4 Non-neuronal specialized cell types.- iPSC-based drug screening of differentiated cardiomyocyte subtypes.- iPSC-based cardiac disease modeling: from cell to tissue.- iPSC-derived corneal endothelial cell.- iPSC-derived trabecular meshwork (eye).- iPSC for in vitro disease modeling of diabetes.