Homology Modeling of Human NK-1 Receptor and Docking Study

ISBN-13: 9783659804205 / Angielski / Miękka / 2015 / 92 str.

Gupta Manish K.;Kumar Viney

Opis

Neurokinin-1 (NK-1) receptor regulates many biological functions related to cancer, such as tumor cell proliferation, angiogenesis and migration of tumor cells for invasion and metastasis. The NK-1 receptor antagonists specifically inhibit tumor cell proliferation, migration of the tumor cells and show antiangiogenic effect. Therefore, the development of NK-1 antagonists for the treatment of cancer is of current interest. The 3D structure of NK-1 is not available from protein data bank. This hampers the design of selective NK-1 antagonists. This book describes the homology modeling of the human NK-1 receptor using multiple templates to provide structural basis for the design of new NK-1 inhibitors and anticancer agents. The authors anticipate that the book will be very useful for the researchers who are working on the design and development of NK-1 receptor antagonists and anticancer agents.

O autorze

Manish Kumar Gupta (M. Pharm., PhD., Postdoc): Professor of Pharmacy, Lloyd Inst. of Mang. & Tech. Gr. Noida, India. His research work focuses on the ligand and structure based drug design, protein modeling and molecular dynamics simulation studies. He has published several research papers in peer-reviewed journals of ACS, Springer and Elsevier.