High Throughput Mass Spectrometry in Drug Discovery

ISBN-13: 9781119678434 / Angielski / Twarda / 2023 / 350 str.

Hui Zhang; Chang Liu

Spis treści

PrefaceList of abbreviationsSection 1 IntroductionChapter 1 Forty Year Evolution of High Throughput Mass Spectrometry: A Perspective.Thomas R. CoveySection 2 LC-MSChapter 2 The LeadSampler (LS-1) sample delivery system: integrated design and features for high- efficiency bioanalysisBrendon Kapinos and John JaniszewskiChapter 3 Evolution of Multiplexing technology for high throughput LC/MS analysesAdam LatawiecSection 3 ESI-MS without chromatographic separationChapter 4 Direct Online SPE-MS for High-Throughput Analysis in Drug DiscoveryAndrew D. Wagner, Wilson Z. ShouChapter 5 Acoustic Sampling for Mass Spectrometry: Fundamentals and Applications in High- Throughput Drug DiscoveryChang Liu, Lucien Ghislain, Jonathan Wingfield, Sammy Datwani, Hui ZhangChapter 6 Recent advances in ion mobility-mass spectrometry for drug discoveryXueyun Zheng, Dylan H. Ross, Aivett Bilbao, and Richard SmithChapter 7 Differential Mobility Spectrometry and its Application to High Throughput AnalysisBradley B. Schneider, Leigh Bedford, Chang Liu, Eva Duchoslav, Yang Kang, Subhasish Purkayastha, Aaron Stella, Thomas R. CoveySection 4 Special Sample ArrangementChapter 8 Off-line Affinity Selection Mass Spectrometry and its Application in Lead DiscoveryChristopher F. Stratton, Lawrence M. Szewczuk, Juncai MengChapter 9 On-line Affinity Selection Mass SpectrometryHui Zhang, Juncai MengChapter 10 Native Mass Spectrometry in Drug Discovery and DevelopmentMengxuan Jia, Jianzhong Wen, Olivier Mozziconacci, Elizabeth PiersonSection 5 Other Ambient Ionization other than ESIChapter 11 Laser Diode Thermal Desorption-Mass Spectrometry (LDTD-MS): Fundamentals and Applications of sub-second analysis in Drug discovery environmentPierre Picard, Sylvain Letarte, Jonathan Rochon, Réal E. PaquinChapter 12 Accelerating Drug Discovery with Ultrahigh-Throughput MALDI-TOF MSSergei DiklerChapter 13 Development and applications of DESI-MS in drug discoveryWenpeng ZhangSection 6 ConclusionChapter 14 The impact of HT-MS to date and it's potential to shape the future of metrics-based experimentation and analysisMathew D. TroutmanIndex

O autorze

Chang Liu, Ph.D., is a Staff Research Scientist at SCIEX, a global leader in the design and production of mass spectrometers. He has published extensively on using mass spectrometry in drug discovery and development.Hui Zhang, Ph.D., is the Vice President of Analytical Technologies at Entos, a biotech company focusing on Artificial Intelligence and High-Throughput Experimentation driving drug discovery. He has published widely on mass spectrometry and its pharmaceutical applications through his previous tenure at Pfizer.