Heterocyclic Compounds: Anti-inflammatory Agents

ISBN-13: 9786204736150 / Angielski / Miękka / 100 str.

Rambabu Gundla; Naresh Kumar Katari; Satyanarayana Yatam

Opis

Inflammation is the body's attempt at self-protection to remove harmful stimuli and begin the healing process, which involves immune cells, blood vessels and molecular mediators, towards the harmful stimuli. The inflammatory response is in three different phases:(A) An acute phase(B) A sub-acute phase(C) A chronic proliferative phase The Mercapto Benzothiazole Linked 1,2,4-Oxadiazole derivatives were designed by Bioisosteric replacement designing approach and synthesized. The 2-Mercapto Benzooxazole linked 1,2,4-Oxadiazoles were designed by scaffold hopping approach and synthesised. The 2-Mercapto Benzothiazole Coupled Benzyl Triazoles compounds were designed by scaffold-Hopping approach and synthesised. All these compounds were biologically evaluated as anti inflammatory agents by targeting COX-1, COX-2, and LOX-5.

O autorze

Gundla, RambabuProf.Rambabu Gundla was formed HoD, Dept. of Chemistry, GITAM, Hyderabad, India. He has 85 publications, 5 patents, 2 projects and 2 books.Dr. Naresh Kumar Katari, is working as an Asst. Prof. Dept. of Chemistry, GITAM, Hyderabad, India. He has published over 100 research papers & 2books. Dr.Satya Y, research scholar, Dept.of Chemistry, GITAM-Hyd.