Heterocycles in Organic Synthesis: Their Synthesis and Applications

ISBN-13: 9783843378444 / Angielski / Miękka / 2010 / 232 str.

Barghash, Reham F.

Opis

Based on the recorded pharmacological potencies of numerous substituted pyrimidines as antihyperlipemic and antihypertensive agents, synthesis of condensed and spiro bis-heterocyclic systems; oxazole-pyrimidines as well as pyrimido-oxazines; bearing a phosphonate substituent was undertaken. The bioassay indicated that some of the products have effect on the central nervous system (CNS), and other products have good selective anti-tumor activity and the structure-activity relationship (SAR) of new phosphonates has also been indicated. In addition, a new class of C-glycosyl amino acids bearing a thiourea segment as a linker has been designed and synthesized by addition of glycosylmethyl isothiocyanates to an amine-functionalized amino acid. The orthogonal set of protective groups makes these compounds suitable substrates for the co-translational modification of natural peptides. The study included the synthesis of a set of new sugar isothiocyanates and their coupling with the alanine derivative.

O autorze

Reham F. Barghash (born in Cairo, Egypt). At present, she is a Researcher at National Research Centre (NRC), Egypt; spent 2 years in Italy at Ferrara Univ. as Associate Researcher; received NRC award for the best Ph.D. thesis 2009. Her research interests in chemistry provide new products for biochemical and pharmaceutical studies and applications.