Heat Shock

ISBN-13: 9783642766817 / Angielski / Miękka / 2011 / 320 str.

Bruno Maresca; Susan Lindquist

Opis

During the last years the heat shock response has been stu- died as a model system to analyze control mechanisms regula- ting the synthesis of heat shock proteins providing impor- tant general insight into the regulation of gene expression. But the major revelation, which has sparked interest from all quarters of biology, is the discovery that heat shock proteins play major roles in an extraordinary variety of normal cellular processes. They are the focus of investiga- tions in many areas of cell biology, including protein traf- ficking, signal transduction, DNS replication, transcrip- tion, protein synthesis, and in the assembly of di- verse protein structures. These aspects are thoroughly trea- ted in the book, as are the implications in immunology, in- fec- tious diseases, chronic degeneration, hyperthermia, and can- cer research.

Spis treści

Analysis of Heat Shock Regulation.- Transcriptional Activation of Drosophila Heat Shock Genes.- Structure and Function of Drosophila Heat Shock Factor.- In vivo and in vitro Studies on the Activation and Binding of Human Heat-shock Transcription Factor.- Mechanisms of Regulation of Small Heat Shock Protein Genes in Drosophila.- Heat Shock Protein Functions in E. coli and Yeast.- The Biological Role of the Universally Conserved E. coli Heat Shock Proteins.- E. coli Mutants Lacking the dnaK Heat Shock Gene: Identification of Cellular Defects and Analysis of Suppressor Mutations.- DnaJ and DnaK Heat Shock Proteins Activate Sequence Specific DNA Binding by RepA.- HSP70 Family of Proteins of the Yeast S. cerevisiae.- Ubiquitin-Conjugating Enzymes Mediate Essential Functions of the Stress Response.- Analysis of Heat Shock Protein Functions.- Early Effects of Heat Shock on Enzymes: Heat Denaturation of Reporter Proteins and Activation of a Protein Kinase which Phosphorylates the C-Terminal Domain of RNA Polymerase II.- Interaction of HSP47 with Newly Synthesized Procollagen, and Regulation of HSP Expression.- In vitro Inhibition of Nascent Polypeptide Formation by HSP70 Proteins.- HSP90, a Carrier of Key Proteins that Regulates Cell Function.- Genetic Analysis of Heat Shock Protein Functions in Yeast.- The Stress Response in the Freshwater Polyp Hydra.- Heat Shock Response during Morphogenesis in the Dimorphic Pathogenic Fungus Histoplasma capsulatum.- Effects of Heat Shock on Development and Actin mRNA Stability in Drosophila.- Heat Shock Proteins and Translocations.- Role of HSP60 in Folding/Assembly of Mitochondrial Proteins.- Role of Heat Shock Proteins in Mitochondrial Protein Import.- A Role for the 73-kDa Heat Shock Cognate Protein in a Lysosomal Pathway of Intracellular Protein Degradation.- Immunology.- Immune Recognition of Stress Proteins in Infection and in Surveillance of Stressed Cells.- Heat Shock Proteins and Mycobacterial Infection.- Heat Shock Proteins and Antimicrobial Immunity.- Heat Shock Proteins and Antigen Processing and Presentation.- Recognition of Heterologous and Autologous Stress Protein Sequences by Heat Shock Reactive ??T Lymphocytes.- Expression of Stress Proteins on the Surface of Cells of the Immune System.- Medical Applications of Heat Shock Response.- Quantification of Protein Denaturation with Sulfhydryl Agents: Application to Heat Shock in Mammalian Cells.- Stable Expression of Human HSP70 Gene in Rodent Cells Confers Thermal Resistance.- The Role of HSP90 in Tumor Specific Immunity.- Heat Shock and Oxidative Injury in Human Cells.- Induction of HSP70 Genes in the Mammalian Nervous System by Hyperthermia, Tissue Injury and Other Traumatic Events.- Ubiquitin and the Lysosomal System: Molecular Pathological and Experimental Findings.