Handbook of Toxicology of Chemical Warfare Agents

ISBN-13: 9780128190906 / Angielski / Twarda / 2020 / 1308 str.

Ramesh C. Gupta

Spis treści

Section I: Historical Perspective and Epidemiology 1. History of Toxicology: From Killers to Healers; 2. Historical Perspective of Chemical Warfare Agents; 3. Global Impact of Chemical Warfare Agents Used Before and After 1945; 4. Sarin Attacks in Japan: Acute and Delayed Health Effects in Survivors; 5. Early and Delayed Effects of Sulfur Mustard in Iranian Veterans After the Iraq-Iran Conflict; 6. Epidemiology of Chemical Warfare Agents; 7. Chemical Weapons of Mass Destruction and Terrorism: A Threat Analysis

Section II: Agents That Can Be Used as Weapons of Mass Destruction 8. Organophosphate Nerve Agents; 9. Russian VX; 10. Novichoks; 11. Blister Agents; 12. Riot Control Agents; 13. Phosgene oxime; 14. Psychotomimetic Agent BZ (3-Quinuclidinyl Benzilate); 15. Fluoroacetate; 16. Strychnine; 17. Superwarfarins; 18. PCBs, Dioxins and Furans: Human Exposure and Health Effects; 19. Polycyclic Aromatic Hydrocarbons: Implications for Developmental, Molecular, and Behavioral Neurotoxicity; 20. Thallium; 21. Arsenicals: Toxicity, Their Use as Chemical Warfare Agents, and Possible Remedial Measures; 22. Chlorine; 23. Phosgene; 24. Carbon Monoxide: Can't See, Can't Smell, Body Looks Red But They Are Dead; 25. Acute Cyanide Toxicity and its Treatment: The Body is Dead and Maybe Red but Does Not Stay Red for Long; 26. Methyl Isocyanate: The Bhopal Gas; 27. Other Toxic Chemicals as Potential Chemical Warfare Agents; 28. Ricin; 29. Botulinum Toxin; 30. Onchidal and Fasciculins; 31. Cyanobacterial (Blue-Green Algae) Toxins

Section III: Target Organ Toxicity 32. Chemical Warfare Agents and the Nervous System; 33. Behavioral Toxicity of Nerve Agents; 34. The Respiratory Toxicity of Chemical Warfare Agents; 35. Cardiovascular System as a Target of Chemical Warfare Agents; 36. Ocular Toxicity of Chemical Warfare Agents; 37. Skeletal Muscle; 38. Dermal Toxicity of Sulfur Mustard; 39. Reproductive Toxicity and Endocrine Disruption of Potential Chemical Warfare Agents; 40. Liver Toxicity of Chemical Warfare Agents; 41. Renal System; 42. Impact of Chemical Warfare Agents on the Immune System

Section IV: Special Topics 43. Health Effects of Nuclear Weapons and Releases of Radioactive Materials; 44. Clinical and Cellular Aspects of Traumatic Brain Injury; 45. Neurological Effects and Mechanisms of Blast Overpressure Injury; 46. Genomics and Proteomics in Brain Complexity in Relation to Chemically-Induced PTSD; 47. Excitotoxicity, Oxidative Stress, and Neuronal Injury; 48. Blood-Brain Barrier Damage and Dysfunction by Chemical Toxicity; 49. The Effects of Organophosphates in the Early Stages of Human Skeletal Muscle Regeneration; 50. Experimental modeling for delayed effects of organophosphates; 51. Alternative Animal Toxicity Testing of Chemical Warfare Agents

Section V: Toxicokinetics, Toxicodynamics and Physiologically-Based Pharmacokinetics 52. Toxicokinetic Aspects of Nerve Agents and Vesicants; 53. Toxicokinetics and Toxicodynamics of DFP; 54. Physiologically Based Pharmacokinetic Modeling of Chemical Warfare Agents; 55. Biotransformation of Warfare Nerve Agents

Section VI: Analytical Methods, Biosensors and Biomarkers 56. Laboratory Analysis of Chemical Warfare Agents, Adducts, and Metabolites in Biomedical Samples; 57. On-Site Detection of Chemical Warfare Agents; 58. Neuropathy Target Esterase as a Biomarker and Biosensor of Delayed Neuropathic Agents; 59. The crosslinking action of organophosphorus poisons; implications for chronic neurotoxicity; 60. Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents

Section VII: Risks to Animals and Wildlife 61. Potential Agents That Can Cause Contamination of Animal Feed stuff and Terror; 62. Chemical Warfare Agents and Risks to Animal Health; 63. Threats to Wildlife by Chemical and Warfare Agents

Section VIII: Emergency Preparedness, Prophylactic, Therapeutic and Countermeasures 64. Pharmacological Prophylaxis Against Nerve Agent Poisoning: Experimental Studies and Practical Implications; 65. Prophylactic and Therapeutic Measures in Nerve Agents Poisoning; 66. Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling of Countermeasures to Nerve Agents; 67. Research on Medical Countermeasures for Chemical Attacks on Civilians; 68. Pyridinium Oximes in the Treatment of Poisoning with Organophosphorus Compounds; 69. Novel Cholinesterase Reactivators; 70. Paraoxonase (PON1), detoxication of nerve agents, and modulation of their toxicity; 71. The role of carboxylesterases in therapeutic interventions of nerve agent poisoning; 72. Catalytic bioscavengers: the new generation of bioscavenger-based medical countermeasures

Section IX: Decontamination and Detoxification 73. Rapid Decontamination of Chemical Warfare Agents from the Skin