Handbook of Toxicology

ISBN-13: 9781439890134 / Angielski / Twarda / 2014 / 1024 str.

Michael J. Derelanko; Carol Auletta

Opis

The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their specific toxicology fields, the chapters provide both fundamental and applied information. Topics range from General Toxicology, to Genetic Toxicology, Human Clinical Toxicology, Histopathology, Clinical Pathology, Metabolism and Toxicokinetics, Risk Assessment, and more.
New to this edition:

• Completely rewritten chapters covering immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology, providing a fresh perspective on these topics
• Addition of new chapters on Chemical Toxicology, Pharmaceutical Toxicology, Juvenile Toxicology, and Safety Pharmacology
• Updated information dealing with Inhalation Toxicology, Neurotoxicology, and Regulatory Toxicology, which has been consolidated into single chapters for each specialty
• A separate glossary with toxicological terms presented both alphabetically and by toxicological subspecialty

For nearly 20 years, this handbook has remained the only reference book of its kind, designed to facilitate easy access to information related to the various toxicology specialties. This updated edition of a popular reference book reflects current practices and the state of the science of toxicology.

Spis treści

Laboratory Animal Management. General Toxicology. Dermal Toxicology. Ocular Toxicology. In Vitro Methods for the Prediction of Ocular and Dermal Toxicity. Inhalation Toxicology. Neurotoxicology. Immunotoxicology. Renal Toxicology. Developmental and Reproductive Toxicity. Juvenile Toxicology. Endocrine Toxicology. Genetic Toxicology. Carcinogenesis. Histopathology. Clinical Pathology. Metabolism and Toxicokinetics of Xenobiotics. Human Clinical Toxicology. Chemical Toxicology. Pharmaceutical Toxicology. Safety Pharmacology. Risk Assessment. Regulatory Toxicology. Appendix A: LD₅₀ Values. Appendix B: Tables of Comparative Anatomical, Physiological, and Biochemical Data. Appendix C: Mathematics, Symbols, Physical Constants, Conversions, and Statistics. Appendix D: Calculations, Preparation, and Properties of Substances Used in Toxicology. Appendix E: Design and Performance of Toxicology Studies. Appendix F: Organizations and Agencies. Appendix G: Acronyms. Appendix H: Academic Programs in Toxicology. Appendix I: Physical/Chemical Information. Glossary. Index.

O autorze

Michael J. Derelanko, PhD, DABT, FATS, has spent most of his career as a toxicologist in the pharmaceutical and chemical industries. He most recently was director of nonclinical drug safety assessment for Adolor Corporation where he contributed to the discovery and development of novel drugs for nearly ten years. Prior to that, as manager of toxicology and risk assessment for Honeywell International, he supported the company’s chemical businesses for over two decades. He currently is employed by Critical Path Services, a Knoell company, where he provides expertise in toxicology and hazard communication.

Carol S. Auletta, DABT, RAC, MBA, has worked in toxicology research for more than 30 years. She is board certified in toxicology by the American Board of Toxicology and in regulatory affairs by the Regulatory Affairs Professionals Society. Carol has spent her career in the CRO industry and currently serves as a senior director in safety assessment and the director of program management at Huntingdon Life Sciences in East Millstone, New Jersey.