Handbook of Radiopharmaceuticals: Methodology and Applications

ISBN-13: 9781119500544 / Angielski / Twarda / 2021 / 768 str.

Michael R. Kilbourn;Peter J. H. Scott

Spis treści

ForewordPrefaceList of ContributorsAbout the EditorsAbbreviationsPART I: INTRODUCTION TO RADIOPHARMACEUTICALS1. Targeted Diagnostic Radiopharmaceuticals: Design Options for Small Molecule RadiotracersMichael R. Kilbourn2. Concepts and Issues for Therapeutic RadiopharmaceuticalsAlexandra R. Sowa Dumond and Peter J. H. ScottPART II: PRODUCTION OF RADIONUCLIDES3. Production of Short Half-life PET RadionuclidesMichael R. Kilbourn, Melissa E. Rodnick and Mara Clark4. Production of Radionuclides used in SPECTSalma Jivan and Thomas J. Ruth5. Production of Therapeutic RadionuclidesC. Shaun Loveless and Suzanne E. LapiPART III: SYNTHETIC METHODS FOR RADIOPHARMACEUTICALS6. Synthesis of 13N- and 15O-labeled RadiopharmaceuticalsKrishna R. Pulagam, Vanessa Gómez-Vallejo, Fernando López-Gallego, Luka Rejc and Jordi Llop7. Radiochemistry with Carbon-11Stephen Thompson, Steven Kealey, Selena M. Sephton and Franklin I. Aigbirhio8. Fluorine-18 RadiochemistryAllen F. Brooks, Katarina J. Makaravage, Jay Wright, Melanie S. Sanford and Peter J. H. Scott9. Synthesis of 68Ga-labeled RadiopharmaceuticalsBenjamin P. Burke and Stephen J. Archibald10. Cu-Mediated Radiohalogenation of OrganoboranesSean W. Reilly and Robert H. Mach11. The radiochemistry of zirconiumJason P. Holland12. 99mTc Radiopharmaceutical ChemistryDionysia PapagiannopoulouPART IV: PRACTICAL ASPECTS OF RADIOPHARMACEUTICAL PRODUCTION AND USE13. Automated Synthesis Modules for PET RadiochemistryLaura Bruton and Peter J. H. Scott14. Automation of PET Radiopharmaceutical Quality ControlArkadij Elizarov15. Moving PET Drugs from the Lab to the Patient in USADavid W. Dick16. Moving from the Lab to the Patient in AsiaDae Yoon Chi17. Moving a radiotracer form bench to bedside in EuropeKoen Vermeulen, Alfons Verbruggen, Guy Bormans and Frederik CleerenPART V: MAJOR APPLICATIONS OF RADIOPHARMACEUTICALS18. Radiopharmaceuticals in OncologyJeroen A.C.M. Goos, Outi Keinänen, Brian M. Zeglis and Jason S. Lewis19. Neurological applications of RadiopharmaceuticalsMehdi Djekidel and Nicolaas I. Bohnen20. Cardiac Applications of RadiopharmaceuticalsJohn P. Bois and Robert J. Gropler21. Radiopharmaceuticals in Pediatric Nuclear MedicineScott E. Snyder, Elizabeth R. Butch and Barry L. Shulkin22. PET Imaging in Drug Discovery and DevelopmentDavid J. DonnellyINDEX

O autorze

Edited byMichael R. Kilbourn, PhD, is Professor Emeritus, Radiology, at the University of Michigan. He retired after 25 years of directing and expanding the University's PET Cyclotron and Radiochemistry program. Professor Kilbourn is the author of over 200 peer-reviewed scientific papers and 31 book chapters, and is the 2009 recipient of the Paul C. Aebersold Award for Outstanding Achievements in Basic Science Applied to Nuclear Medicine.Peter J. H. Scott, PhD, is Associate Professor, Radiology, and Director of the PET Center at the University of Michigan. His research focuses on developing new methods for radiolabeling bioactive molecules and the design and synthesis of new radiotracers for PET imaging. Professor Scott has published over 100 papers, 170 abstracts, and 30 book chapters, edited 4 books, and is listed as an inventor on multiple patents. In 2019 he received a Distinguished Investigator Award from the Academy for Radiology & Biomedical Imaging Research.