Gut and the Liver

ISBN-13: 9780792387367 / Angielski / Twarda / 1998 / 430 str.

H. E. Blum; R. B. Sartor; J. Ch Bode

Opis

This book, the proceedings of Falk Symposium 100, Gut and the Liver', held in Freiburg, Germany, 29-31 May 1997, comprehensively reviews the physiological and pathophysiological interactions between the intestine and the liver as well as between intestinal and hepatic diseases. Apart from the basic aspects of the intestinal microflora and the immune system of the gut, gastrointestinal permeability and translocation as well as the contribution of the intestine and the intestinal bacteria to the metabolism of bile acids, amino acids and drugs are discussed. In addition, experimental as well as clinical data demonstrating the significance of gut-derived bacterial toxins for the development of liver diseases and the effect of liver diseases on gastrointestinal functions are discussed. The major aim of this book, therefore, is to highlight the interactions between gut and liver at the molecular level as well as in clinical disease.

Spis treści

Preface. Section I: The `Milieu Extérieur' and `Milieu Intérieur' in the Gut: Confrontation and Cooperation. 1. Intestinal Microbiota: Control and Overgrowth; A.B. Onderdonk. 2. The Intestinal Immune System; T. Marth, M. Zeitz. Section II: Gastrointestinal Permeability and Translocation. 3. The Intestinal Permeability Barrier - What is Measured, What Does It Mean; S. Gabe, et al. 4. Bacterial Translocation; R.D. Berg. 5. Intestinal Permeability in Inflammatory Bowel Disease; 6. Intestinal Absorption of Small Particles; J. Seifert. Section III: Bile Acid, Amino Acid and Drug Metabolism - It's Not Only the Liver, it May be the Gut. 7. State of the Art Lecture: Bacterial Enzymes and Bile Acid Metabolism: Peaceful Coexistence vs. Deadly Warfare; A.F. Hofmann. 8. Gastric First Pass Metabolism of Alcohol: Interaction with Ammonia and Associated Gastritis; C.S. Lieber. 9. Ethanol Oxidation and Acetaldehyde Production by Colonic Microbes; M. Salaspuro, et al. 10. Adaptation of Liver Cell Function to Enteral Resorption: Role of Cell Liver Hydration; D. Hässinger, et al. 11. Amino Acid Metabolism in the Gut; M. Plauth, A.E. Roske. 12. Drug Metabolism in the Intestinal Wall; U. Klotz. The Role of Gut Bacteria in Drug Metabolism; T.M. Bauer. Section IV: Gut-Derived Bacterial Toxins and Liver Injury. 14. How Bacterial Toxins Affect the Intestinal Mucosa - Molecular Mechanism of the Action of Clostridium Difficile Toxins; K. Aktories. 15. Acute and Chronic Endotoxemia: Effects on Hepatic Neutrophil Influx and Respiratory Burst; J.A. Spitzer. 16. Experimental Liver Injury: The Role of Lipopolysaccharides and Cytokines; A. Wendel, et al. 17. Endotoxin, Kupffer Cells and Alcoholic Liver Injury; R.G. Thurman, et al. 18. Hepatic Injury and Biliary Tract Diseases Associated with Small Intestinal Bacterial Overgrowth; R.B. Sartor, S.N. Lichtman. 19. Endotoxemia in Chronic Hepatitis and Cirrhosis: Epiphenomenon or of Pathological Relevance? H. Fukui, et al. 20. Endotoxemia and Disseminated Intravascular Coagulation in Cirrhosis; F. Violi, et al. 21. The Role of Gut-Derived Bacterial Toxins (Endotoxin) for the Development of Alcoholic Liver Disease in Man; Ch. Bode, et al. 22. Endotoxaemia and Cholestasis; E. Walter. 23. Adverse Effects of Gut-Derived Bacterial Toxins in Liver Transplantation; W. Lauchart. Section V: Gastrointestinal Dysfunction in Liver Disease. 24. Altered Gastrointestinal Motility in Chronic Liver Disease; R.K. Zetterman. 25. Portal Hypertensive Intestinal Vasculopathy; T.R. Viggiano. 26. Role of Lipopolysaccharide and Inducible Nitric Oxide Synthase in Gastrointestinal and Hepatic Disease: Actions of Selective Inhibition of iNOS on Microvascular Integrity in the Gut and Liver; F. László, et al. 27. Bacterial Overgrowth in the Small Intestine in Chronic Liver Disease; F. Casafont, et al. Section VI: Spontaneous Bacterial Peritonitis in Cirrhotics. 28. Spontaneous Bacterial Peritonitis Incidence, Diagnosis and Clinical Course; A. Ochs. 29. Treatment and Prophylaxis of Spontaneous Bacterial Peritonitis; A. Rimola, et al. Section VII: Liver Injury in Patients with Diseases of the Gastrointestinal Tract. 30. Haemochromatosis: A Defect in Gut Transport Leads to Liver Injury; W. Stremmel, et al. 31. Liver and Biliary Abnormalities in Ulcerative Colitis and Crohn's Disease; R.H. Wiesner. 32. Liver Abnormalities in Coeliac Disease; M.B. Jacobsen. 33. Primary Sclerosing Cholangitis: New Therapeutic Strategies; A. Stiehl, et al. 34. Jejunoileal Bypass: An Unintended Model of Steatophepatitis (Nash Syndrome) in Man; D.L. Kaminski. Index.