Gpcrs: Structure, Function, and Drug Discovery

ISBN-13: 9780128162286 / Angielski / Miękka / 2019 / 500 str.

Beata Jastrzebska; Paul S. H. Park

Spis treści

Part I GPCR structure 1. Progress in GPCR structure Determination 2. Structure, function and therapeutic potential of adhesion GPCRs 3. Structural diversity in ligand recognition by GPCRs 4. NMR-based approaches to the study of GPCRs and GPCR-ligand interactions 5. Supramolecular structure of opsins 6. Molecular determinants of GPCR oligomerization 7. Structure of G-protein-coupled receptor heteromers 8. Class A GPCR oligomerization: reasons of controversy

Part II GPCR function 9. Quantifying GPCR allostery and biased signaling 10. Kinetics of ligand binding and signaling 11. Allosteric modulators targeting GPCRs 12. Arrestin-mediated signaling at GPCRs 13. Organellar Gb? signaling - GPCR signaling beyond the cell surface

Part III GPCRs in disease and targeted drug discovery 14. G protein-coupled receptor allosteric modulators: understanding modulator affinity and pharmacological dose 15. Computer-aided GPCR drug discovery 16. Tackling the complexities of orphan GPCR ligand discovery with rationally assisted approaches 17. G protein-coupled receptors in neurodegenerative diseases 18. GPCR targets in type 2 diabetes 19. GPCRs in thromboinflammation and hemostasis 20. Angiotensin II receptors: structure-function and drug discovery 21. GPCRs in innate and adaptive immune responses 22. Role of GPCRs in cancer