Glucocorticoid Signaling: From Molecules to Mice to Man

ISBN-13: 9781493949977 / Angielski / Miękka / 2016 / 385 str.

Jen-Chywan Wang Phd; Charles Harris MD Phd

Opis

The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research.

Spis treści

Section 1: Introductory Materials

Ch. 1: Regulatory actions of glucocorticoid hormones: from organisms to
mechanisms

Daryl K. Granner, Jen-Chywan Wang, Keith R. Yamamoto

Ch. 2: Molecular Biology of Glucocorticoid Signaling

Margarita Arango-Lievano, Lambert W. Marcus, Freddy Jeanneteau

Ch. 3: Mechanisms of Glucocorticoid-regulated Gene Transcription

Sebastiaan H. Meijsing

Ch. 4: Clinical perspective: What do Addison and Cushing tell us about
glucocorticoid action?

Charles Harris

Section 2: Effects of glucocorticoids on metabolism

Ch. 5: Regulation of Glucose Homeostasis by Glucocorticoids

Taiyi Kuo, Allison McQueen, Tzu-Chieh Chen, Jen-Chywan Wang

Ch. 6: How do glucocorticoids regulate lipid metabolism?

Roldan M. de Guia, Stephan Herzig

Ch. 7: Glucocorticoids and Skeletal Muscle

Sue C. Bodine, J. David Furlow

Section 3: Specific Effects of Glucocorticoids on tissues

Ch. 8: Glucocorticoid- induced osteoporosis

Baruch Frenkel, Wendy White, Jan Tuckermann

Ch. 9: Effects of glucocorticoids in the immune system
Emmanuel Oppong, Andrew C. B. Cato

Ch. 10: Glucocorticoids and the brain: neural mechanisms regulating the stress
response

Shawn N. Shirazi, Aaron R. Friedman, Daniela Kaufer, Samuel A.
Sakhai

Ch. 11: Glucocorticoid Regulation of Reproduction

Anna C. Geraghty, Daniela Kaufer

Ch. 12: Glucocorticoids and the lung

Anthony Gerber

Ch. 13: Glucocorticoids and the Cardiovascular System

Julie Goodwin

Ch. 14: Glucocorticoids and Cancer

Miles Pufall

Section 4: Miscellaneous Topics

Ch. 15: Animal models of altered glucocorticoid signaling

Charles Harris

Ch. 16: The Dehydrogenase hypothesis

Conor Woods, Jeremy W Tomlinson

Ch. 17: Conclusions and Future Directions

Jen-Chywan Wang, Charles Harris

Blurb

This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.