Genomic Instability and Cancer Metastasis: Mechanisms, Emerging Themes, and Novel Therapeutic Strategies

ISBN-13: 9783319352954 / Angielski / Miękka / 2016 / 247 str.

Chris Maxwell; Cal Roskelley

Opis

Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse.

Recenzje

"This book connects cancer metastasis, the major cause of death in patients with malignancy, with genomic instability. For oncologists and biologists." (Pediatric Endocrinology Reviews (PER), Vol. 12 (4), 2015)

Spis treści

Preface

Chapter 1 Cancer Metastasis: Tracking and Attacking a Moving Target

Chapter 2 The generation, detection, and prevention of genomic instability during cancer progression and metastasis.

Chapter 3 DNA damage response pathways in cancer predisposition and progression

Chapter 4 Mathematical modeling for DNA repair, carcinogenesis and cancer detection

Chapter 5 Animal models of metastasis

Chapter 6 Microenvironmental Control Of Metastatic Progression.

Chapter 7 Mechanotransduction, metastasis and genomic instability

Chapter 8 Immunomodulation and Genomic Instability

Chapter 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability.

Chapter 10 Nanomedicine – Nanoparticles in Cancer Imaging and Therapy

Index.

Blurb

Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1  outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.