Genetic Immunization & Cytokine Immunomodulation » książka
Genetic Immunization & Cytokine Immunomodulation
ISBN-13: 9783847312390 / Angielski / Miękka / 2011 / 132 str.
In chronic parasitic infections, the interplay between the host and the parasite suggests immuno-suppressive mechanisms developed by the parasite. Echinococcus granulosus, a tiny tapeworm that among other helminthes, favors the induction of T helper type 2 responses which are less severe and less destructive than T helper type 1 responses. This study aimed at exploring the immune response generated in BALB/c mice using genetic immunization technology. Immuno-modulation by the co-delivery of different cytokine genes (IFN-γ, IL-12, IL-4) was also investigated. Immunization by antigen B or its second subunit (EgAgB8/2) revealed dominated T helper type 2 cytokine response, IgG3 humoral response, low splenocyte cell proliferation, and low CD8+ cell count. However, restored CD8+ cell count, high splenocyte cell proliferation, and high expression of IFN-γ cytokine in IFN-γ gene co-immunized mice indicates the efficiency of cytokine gene immuno-modulation in skewing the response toward T helper type 1.
In chronic parasitic infections, the interplay between the host and the parasite suggests immuno-suppressive mechanisms developed by the parasite. Echinococcus granulosus, a tiny tapeworm that among other helminthes, favors the induction of T helper type 2 responses which are less severe and less destructive than T helper type 1 responses. This study aimed at exploring the immune response generated in BALB/c mice using genetic immunization technology. Immuno-modulation by the co-delivery of different cytokine genes (IFN-γ, IL-12, IL-4) was also investigated. Immunization by antigen B or its second subunit (EgAgB8/2) revealed dominated T helper type 2 cytokine response, IgG3 humoral response, low splenocyte cell proliferation, and low CD8+ cell count. However, restored CD8+ cell count, high splenocyte cell proliferation, and high expression of IFN-γ cytokine in IFN-γ gene co-immunized mice indicates the efficiency of cytokine gene immuno-modulation in skewing the response toward T helper type 1.
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