Genetic Epidemiology

ISBN-13: 9781603274159 / Angielski / Twarda / 2010 / 242 str.

D. Teare; Dawn Teare

Opis

Arising from firm foundations laid by mathematical population genetics, clinical genetics, and statistical epidemiology, genetic epidemiology attempts to identify the many components of risk

attributable to genes, environments, and interactions, and the course of its research can follow many diverse paths. In "Genetic Epidemiology," the success of genome-wide association studies in their identification of hundreds of disease susceptibility loci has inspired renowned experts to contribute thorough methodologies, which aim to bring together bioinformaticians, geneticists, clinicians, statisticians, and epidemiologists in the study of this vital field. The volume opens with chapters covering the basics; however, it quickly moves on to coverage of more specialist topics such as twin studies, Mendelian randomization, genetic association studies, more advanced areas, as well as case studies. As a part of the highly successful "Methods in Molecular Biology " series, this work provides the detailed description of the application and analysis of the most commonly employed methods that are necessary for a firm grounding in the field.

Authoritative and cutting-edge, "Genetic Epidemiology" aims to provide a basic framework for crucial interdisciplinary communication and understanding suited to newcomers to the field as well as experienced researchers and graduate level students.

Spis treści

Part I: Introduction

 

1. Molecular Genetics and Genetic Variation

            Mohammed Elfatih Twfieg and M. Dawn Teare

 

2. Terminology, Concepts, and Models in Genetic Epidemiology

            M. Dawn Teare and Mauro F Santibàñez Koref

 

3. An Introduction to Epidemiology

            Cother Hajat

 

Part II: Genetic Linkage Mapping

 

4. Genetic Distance and Markers Used in Linkage Mapping

            Kristina Allen-Brady and Nicola J. Camp

 

5. Approaches to Genetic Linkage Analysis

            M. Dawn Teare

 

Part III: Genetic Mapping by Association

 

6. Fine-Scale Structure of the Genome and Markers Used in Association Mapping

            Karen Curtin and Nicola J. Camp

 

7. Genome-Wide Association Studies

            Mark M. Iles

 

8. Candidate Gene Association Studies

            M. Dawn Teare

 

9. Family-Based Association Studies

            Frank Dudbridge

 

10. Genome Variation: A Review of Web Resources

            Andrew Collins and William Tapper

 

Part IV: Emerging Themes

 

11. Advanced Methods in Twin Studies

            Jaakko Kaprio and Karri Silventoinen

 

12. Mendelian Randomization: A Tool for Assessing Causality in Observational Epidemiology

            Nuala A. Sheehan, Sha Meng, and Vanessa Didelez

 

13. Copy Number Variation

            Louise V. Wain and Martin D. Tobin

 

14. Epigenetic Variation

            Kevin Walters

 

Part V: Case Studies

 

15. Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis

            Hervé Perdry and Françoise Clerget-Darpoux

 

16. Coronary Artery Disease: An Example Case Study

            Jennifer H. Barrett

 

17. The Genetic Epidemiology of Obesity: A Case Study

            Laura Johnson