Gene Delivery by Protein-Polymer Nanoconjugates

ISBN-13: 9786200232229 / Angielski / Miękka / 2019 / 72 str.

Heidar-Ali Tajmir-Riahi

Opis

In this book, we explore the potential applications of protein-polymer nanoconjugates in gene delivery. Conjugation of human serum albumin (HSA), bovine serum albumin (BSA) and beta-lactoglobulin (beta-LG) with chitosan (carbohydrates) and PAMAM (dendrimers) of different sizes were used to transport DNA and RNA. Thermodynamic analysis showed that the conjugation of DNA and RNA to protein-polymer nanoparticles occurred via hydrophilic, hydrophobic, H-bonding and van der Waals contacts. As the size of portion-polymer nanoconjugate increased, the loading efficacy of DNA and RNA was increased (40% to 60%). Major alterations of DNA and RNA morphology occurred by nanoparticle interaction. Protein-polymer nanoconjugates are capable of delivering DNA and RNA to the target molecules.

O autorze

Tajmir-Riahi, Heidar-Ali
Heidar-Ali Tajmir-Riahi: Research Professor at University of Quebec in Trois-Rivieres (UQTR), Canada. He was admitted to the Circle of Excellence of Quebec University in 2017. He has 360 publications in international journals with 12 books and 15 book chapters. Research interest: drug interactions with DNA, RNA and proteins; drug delivery.