Garner's aldehyde : An important chiral - amino aldehyde in organic chemistry

ISBN-13: 9786200275783 / Angielski

Moumita Ghosh

Opis

Chiral amino aldehydes are remarkable, as their aldehyde groups can be converted into a wide range of structural frameworks are the intermediates in several important industrial processes. However, the characteristic reactivity of amine and aldehyde functionalities is a major task in case of preparation and synthetic efficacy of -amino aldehydes as nitrogen protection assists undesired epimerization processes. Fischer's discovery of glucosamine in 1902 in which unprotected amine and aldehyde functionalities are stabilized as a cyclic hemiacetal is the first example of unprotected -amino aldehydes. Later on, he also synthesized glycinal, which was characterized through degradation studies due to its inherent instability via self-condensation. The probability for intramolecular stabilization of -amino aldehydes is not significant but the presence of incompatible functional groups make these unstable and hence, suitable N-and C-protection is vital.

O autorze

Ghosh, Moumita
Moumita Ghosh, working as an Assistant Professor in IITE Gandhinagar, India. She is an Inorganic Chemist. As an adjunct scholar in Gujarat University. Her areas of research are Asymmetric organic synthesis, Metal Organic Framework and drug delivery system.