Gallstones: Pathogenesis and Treatment

ISBN-13: 9780792387985 / Angielski / Twarda / 2004 / 246 str.

G. Adler; H. E. Blum; M. Fuchs

Opis

This book, the proceedings of the Falk Syposium No. 139 on -Gallstones: Pathogenesis and Treatment-, held in Freiburg, Germany, on January 15-16, 2004, reflects the tremendous advances in the field of biliary diseases both at the genetic and cellular as well as the clinical levels. In industrialized countries, gallstones are a frequent clinical entity with a prevalence of 10-15%. In clinical practice one can differentiate between cholesterol stones, black pigment stones and brown pigment stones. 80-90% of gallbladder stones are cholesterol stones, 10--20% are black pigment stones. The prevalence of cholesterol stones increases with age and in Europe in the 70+ age group reaches about 20% in males and about 30% in females. Gallstones and gallstone diseases, therefore, are a frequent and important clinical problem. The book addresses the basic aspects of gallstone pathogenesis as well as the non-surgical and surgical treatment of gallstone diseases. Of particular interest are the epidemiology and genetics of gallstone formation, with definition of risk factors, in particular of genetic predispositions. Other major aspects are the hepatocellular and bilary transport mechanisms that predispose to the formation of gallstones. Apart from cholesterol and lipid transport and absorption, gallbladder function plays a central role in gallstone formation. Another clinically very relevant topic is the treatment of gallstone diseases by drugs, endoscopic and other non-surgical interventions, and surgery, as well as the long-term outcome of therapeutic interventions. The volume concludes with a state-of-the-art chapter on -Gallstone Research in the Post-Genomic Era-. Gallstones: Pathogenesis and Treatment is an excellent update on the pathogenesis of gallstones as well as on the treatment of gallstone diseases, written by an international faculty of outstanding clinicans and scientists. The book will, therefore, be of great interest to hepatologists and gastroenterologists in academic institutions as well as in clinical practice.

Spis treści

List of principal contributors. Preface. Section I: Epidemiology And Genetics. 1: Risk factors and natural history of gallstone disease; W Kratzer. 2: Low phospholipid-associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene; O Rosmorduc, R Poupon. 3: Cholesterol 7 alpha-hydroxylase (CYP7A1) gene mutation: another cause for gallstone formation?; CR Pullinger, C Eng, MJ Malloy, JP Kane. 4: Cystic fibrosis transmembrane conductance regulator gene mutations cause `black' pigment gallstone formation: new insights from mouse models and implications for therapeutic interventions in cystic fibrosis; AL Broderick, H Wittenburg, MA Lyons, KDR Setchell, AF Hofmann, MC Carey. 5: Molecular genetics of gallstone formation: human association studies and comparative genomics; F Lammert, HE Wasmuth, S Matern. Section II: Biliary Lipid Secretion. 6: Hepatocellular transport of cholesterol; M Fuchs. 7: Effect of an Abcc2 missense mutation on biliary lipid secretion and lithogenicity of bile; G Bouchard, MC Carey, B Paigen. 8: The role of ABCG5 and ABCG8 in biliary lipid secretion; E Vink, A Kosters, RJJM Frijters, AK Groen. 9: Biphasic response of hepatobiliary cholesterol metabolism to leptin at the onset of diet-induced obesity; S Roy, DE Cohen. 10: Epidemiology and molecular pathogenesis of primary hepatolithiasis; J Shoda, N Tanaka, T Osuga. 11: Bilirubin and cholesterol gallstone formation: phospholipase and &bgr;-glucuronidase as factors affecting cholesterol crystallization; S Tazuma, Y Sunami, K Nakai, T Nishioka, H Hyogo, K Kanno, Y Numata, A Yamaguchi, D Komichi, T Kobuke, M Nonaka, K Iwamoto, M Inoue, Y Nabeshima, M Ogi, T Ishitobi, T Ajima, K Chayama. Section III: Gallbladder Function And Lipid Absorption. 12: Gene polymorphisms and impaired gallbladder motility; DM Klass. 13: Molecular dynamics simulation of cholesterol nucleation in mixed micelles modelling human bile; SJ Marrink. 14: Pigment gallstones: an intestinal disease?; N Méndez-Sánchez, N Chavez-Tapia, K Sánchez, J Bordes, M Uribe. 15: Bile acid transporters and cholelithiasis; I Bergheim, S Harsch, O Mueller, S Schimmel, P Fritz, EF Stange. 16: Reconstitution of fat absorption by phosphatidylcholine-cholesterol vesicles during bile deficiency in rats; HJ Verkade, R Havinga, S Tazuma, H Elzinga, F Stellaard, F Kuipers, T Nishioka. Section IV: Non-Surgical Treatment Of Gallstone Disease. 17: Non-surgical treatment of gallbladder stones: still a role for ursodeoxycholic acid?; U Beuers. 18: Prevention of gallstone-related complications with ursodeoxycholic acid; GP van Berge-Henegouwen, NG Venneman, P Portincasa, KJ van Erpecum. 19: Fatty acid bile acid conjugates – novel agents for prevention and treatment of gallstones; FM Konikoff, A Frenkel, T Gilat. 20: Gallstone pancreatitis; KJ van Erpecum, NG Venneman, LP Van Minnen, GP van Berge Henegouwen. 21: Imaging of bile duct stones; M Sackmann, K-D Schmidt. 22: Endoscopic therapy of bile duct stones; H Schwacha. Section V: Surgical Treatment Of Gallstone Disease. 23: Surgical treatment of gallstone disease – always laparoscopic?; UT Hopt. 24: Complications of laparoscopic cholecystectomy; KP Thon. 25: Postcholecystectomy syndrome; D Jüngst, G Straub, G Sauter. 26: State of the art – gallstone research in the post-genomic era; MC Carey, RS Kwon, KJ Maurer, JG Fox. Colour figures. Index.