G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era

ISBN-13: 9781627037785 / Angielski / Twarda / 2014 / 423 str.

Craig W. Stevens

Opis

G Protein‐Coupled Receptor Genetics: Research and Methods in the Post‐Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab.Authoritative and easy to use, G Protein‐Coupled Receptor Genetics: Research and Methods in the Post‐Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.

Spis treści

Part I: Genetic Mechanisms of G Protein-Coupled Receptors

 

1. G Protein-Coupled Receptors: Research and Methods in the Post-Genomic Era

            Craig W. Stevens

 

2. Examining the Dynamic Evolution of G Protein-Coupled Receptors

            Claudia Stäubert, Diana Le Duc, and Torsten Schöneberg

 

3. Functional Properties of Virus-Encoded and Virus-Regulated G Protein-Coupled Receptors

            Katja Spiess and Mette M. Rosenkilde

 

4. Discovery and Function of the Very Large G Protein-Coupled Receptor

            Perrin C. White and D. Randy McMillan

 

5. Functional Evolution of Opioid Family G Protein-Coupled Receptors

            Eyal Vardy, Craig W. Stevens, and Bryan L. Roth

 

6. Investigation of G Protein-Coupled Receptor Function and Regulation Using Antisense

            Jonathon Mark Willets and Craig Nash

 

7. Signalosome Profiling Reveals Allosteric Interactions Between G Protein-Coupled Receptors

            Katrin Altosaar, Darlaine Pétrin, Dominic Devost, and Terence E. Hébert

 

Part II: Genetic Toolbox for G Protein-Coupled Receptor Discovery

 

8. Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptors

            Olivia A. Masseck, Melanie D. Mark, and Stefan Herlitze

 

9. Viral Infection for G Protein-Coupled Receptor Expression in Eukaryotic Cells

            Antonio Porcellini, Luisa Iacovelli, and Antonio De Blasi

 

10. Using In Vitro Mutagenesis to Characterize Structure-Function Relationships in G Protein-Coupled Receptors

            Gregory W. Sawyer and Frederick J. Ehlert

 

11. The CRE Luc Mouse Model for Bioimaging Ligand Activation of G Protein-Coupled Receptors

            H. Gregory Polites and Kyriakos D. Economides

 

12. Inducing Conformational Changes in G Protein-Coupled Receptors by Domain Coupling

            Hamiyet Unal and Sadashiva S. Karnik

 

13. Rescue of Defective G Protein-Coupled Receptor Function by Intermolecular Cooperation

            Ashutosh Trehan, Kim Carol Jonas, Ilpo Huhtaniemi, Aylin Carla Hanyaloglu, and Adolfo Rivero-Müller

 

14. Design of Super-Arrestins for Gene Therapy of Diseases Associated with Excessive Signaling of G Protein-Coupled Receptors

            Vsevolod V. Gurevich and Eugenia V. Gurevich

 

Part III: Genetic Aspects of G Protein-Coupled Receptors in Health and Medicine

 

15. Importance of G Protein-Coupled Receptor Genetics in Clinical Medicine

            Ramakrishna Devaki

 

16. Pharmacogenomics of G Protein-Coupled Receptor Signaling and Other Pathways in Essential Hypertension

            Pedro A. Jose, Van Anthony M. Villar, Matthew R. Weir, and Robin A. Felder

 

17. Exon Sequencing of G Protein-Coupled Receptor Genes and Perspectives for Disease Treatment

            Angeliki Karamitri and Ralf Jockers

 

18. Gene Therapy Using G Protein-Coupled Receptors for the Treatment of Cardiovascular Disease

            Dario Leosco, Grazia D. Femminella, Claudio de Lucia, and Giuseppe Rengo

 

19. Novel Mechanisms of G Protein-Coupled Receptor Oligomer and Ion Channel Interactions in Nociception

            Ajay S. Yekkirala

 

20. Discovery and Characterization of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors

            Marie-Isabelle Garcia, Valeria Fernandez-Vallone, and Gilbert Vassart

 

21. The Role of G-Protein Coupled Receptors in Adult Neurogenesis

            Katie M. Collette, Van A. Doze, and Dianne M. Perez