Further Studies in the Assessment of Toxic Actions: Proceedings of the European Society of Toxicology Meeting, Held in Dresden, June 11 - 13, 1979

ISBN-13: 9783540101918 / Angielski / Miękka / 1980 / 510 str.

P. L. Chambers; W. Klinger

Spis treści

Testing for Mutagenicity and Carcinogenicity.- Assessment of Mutagenicity Tests.- Testing of Medicines for Their Mutagenic Potency. Proposition from a French Working Party (Abstract).- Monitoring the Occupational Exposure to Mutagens by the Cytogenetic Analysis of Human Peripheral Lymphocytes in vivo.- Elevated Mitotic Number in the Adrenal Cortex as a Reflection of Early Events in Growth Induction by Carcinogens and Promoters — A Possible Short-Term Assay.- Sister Chromatid Exchanges in Chinese Hamster Embryonic Liver Cells Exposed Transplacentally to Bromodeoxyuridine (BrdU) and Chemical Mutagens.- Differences in Carcinogenicity After Transplacental and Postnatal Administration of Drugs and Pesticides.- Combination Effects in Chemical Carcinogenesis.- Chromosome Aberration Tests with Chinese Hamster Cells in vitro with and without Metabolic Activation — A Comparative Study on Mutagens and Carcinogens.- Ligand Binding of Safrole to Cytochrome P-450.- Testing of Drugs for Combined Mutagenesis with Sodium Nitrite in the Host-mediated Assay.- Biotransformation and Spectral Interaction of Xenobiotics with Subcellular Fractions from Drosophila Melanogaster.- Mutagenicity of DNOC in Drosophila Melanogaster.- Standardization of Clastogenicity and SCE Assays on Mammalian Cells in vitro — Results and Problems (Abstract).- Influence of Experimental Factors on the Mutagenicity of Vinylic Monomers.- Modification of Mutagenic Activity of Anticancer Drugs (Abstract).- Mutagenic Activity in Foundry Air.- The Effect of Carcinogens and Non-Carcinogens on Some Biochemical Features of the Mouse Lung Tissue (Abstract).- Attempt to Develop New Mouse Colony with High Susceptibility to Carcinogens.- Metabolizing Activities of Postmitochondrial Liver Fractions (S-9) on Benzo[a]-Pyrene and Dimethylnitrosamine.- Reduced Induction of Pyruvate Kinase After Feeding 2-Acetylaminofluorene.- Chemical Carcinogens: Screening, Testing, Risk Assessment for Man (Abstract).- Studies on the Detection of Chemical Carcinogens Using a Mammalian Cell Transformation Assay. A Correlated Study of BHK Cell Transformation and Bacterial Mutagenicity.- Chronic and Carcinogenic Study of Trinitroglycerin in Rats, Mice and Dogs (Abstract).- Induction of Pituitary Tumours and Hyperprolactinemia in Female Rats by Estrogens. The Effect of Apomorphine Reserpine L-DOPA.- Testing for Influence on the Immunological System.- Immunotoxicity Assessment: Screening and Function Studies.- Immunopharmacology and its Toxicological Problems.- Some Approaches to Experimental Testing of Drugs for Immunotoxicity.- Biotransformation and Immunotoxicity.- Effects of Toxicants on T-cell Subpopulations as Determined by Lymphokine Activity.- A Simple Technique of Testing for the Influence of Metal Salts and Other Chemicals on Macrophages and Thymocytes in vitro.- Toxicity of Organotin Compounds in Chicken and Rats.- Inhibition of Immune Response by Diisopropyl Phosphorofluoridate.- Thymocyte Stimulating Activity of the Serum of Rats in the Early Phase After 2-Acetylaminofluorene (AAF)-Treatment.- Lysozyme (Muramidase) and Hemolytic Complement (CH50U) in Sera of Beagle Dogs and Minipigs after Longterm Application of Different Preparations of Estrogens and Gestagens.- The Effect of Acute Administration of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on Humoral Antibody Production and Cell-Mediated Activities in Mice.- Quantitative Development of Immunoglobulin (IgG) During Life-Span of Male and Female Laboratory Rat (Abstract).- Studies on the Action of Dimethoate on the Immune System.- The Effect of DDVP, an Organophosphorus Pesticide, on the Humoral and Cell-Mediated Immunity of Rabbits.- The Relationship Between the Length of the Alkyl Chain of Dialkyltin Compounds and their Effects on Thymus and Bile Ducts in Mice.- Allergic Encephalomyelitis in Rats — Toxicity Assay for Pertussis Vaccines.- Testing for Nephrotoxicity.- Some Aspects of Testing Drugs for Nephrotoxicity in Rats.- Nephrotoxicity of Drugs, Evaluated by Renal Enzyme Excretion Studies.- Urinary Enzyme Excretion and Changes in Renal Functions Induced by Toxic Substances or by Renal Ischemia in Rats.- Stimulation of Kidney Function in Rats Injured by Nephrotoxic Agents.- Relationship Between Exposure to Heavy Metals and Prevalence of Renal Dysfunction.- Nephrotoxicity of the Flame Retardant Tris (2,3-Dibromopropyl) Phosphate.- Paper Presented by the Young Scientists Award Winner 1979: Evaluation of Renal Dysfunction Induced by Cadmium in Man by Determination of Enzymes and Specific Proteins in Urine.- Testing of Drugs for Nephrotoxicity. General Principles and Minimal Criteria.- Testing for Embryotoxicity.- Hydroxyurea as a Reference Standard in Teratological Screening. Comparison of the Embryotoxic and Teratogenic Effects Following Single Intraperitoneal or Repeated Oral Administrations to Pregnant Rats.- Embryotoxic Effects of Post-Coital Fertility Inhibiting Steroids.- Subtle Consequences of Prenatal Exposure to Low Carbon Disulphide Levels.- Behaviour Teratology Tests (Abstract).- Testing for Embryotoxicity.- Morphogenetic Systems and Screening for Embryotoxicity.- The State and Future Requirements of Teratogenic Testing.- Behavioural Tests in Peri- and Post-Natal Toxicity Study in Rats of Trithiozine [4-(3,4,5-trimethoxythiobenzoyl)-tetrahydro-l,4-oxazine].- Influence of Thalidomide on Alkaline (AP) and Acid (ACP) Phosphatase Activities in Rat Fetuses and Mothers (Abstract).- Experiences with a Three Step Test Scheme for Embryotoxicity and Teratogenicity.- Postnatal Effects of Oral Administration of Ethylenethiourea to Rats During Late Pregnancy.- Activity of Some Mixed Function Oxidases in Prenatally Carbon Disulphide (CS2) Treated Rats.- Free Communications.- Endocrine Aspects of Ozone Exposure in Rats.- Significance of Mode of Exposure in Aerosol Inhalation Toxicity Studies — Head only Versus Whole Body Exposure.- Pharmacokinetic Studies with 3H-Cytisine.- Kinetics of Benzene Metabolism in Rats in Inhalation Exposure.- Estimation of Occupational Exposure to Phenoxy Acids (2,4-D and 2,4,5-T).- Acrylonitrile Metabolism in the Rat.- Changes of Pharmacokinetics and Metabolism of Sulfadimidine in Endotoxin Pretreated Rabbits.- Effect of Hydrocortisone on Oxidative Degradation of Hexobarbital and Ethylmorphine.- Study of the Protective Effect of an Anabolic Steroid, 19-Nortestosterone Phenyl-propionate (19-NTPP), on the Fatty Liver Induced by High Doses of Rifampicin in the Rat.- Comparative in vitro Investigations on the Dialysability of Hypnotic and Psychotropic Drugs by Hemodialysis and Controlled Sequential Ultradiffusion.- The Excretion of Ascorbic Acid and Hippuric Acid in the Urine of Rats with Liver Injury.- Evaluation of Liver Function Tests After Administration of Aminophenazone.- Effects of Some Cholephilic Agents on Hepatic Mitochondrial Respiration and Biliary Excretion.- The Fate of Propoxur in Rat.- Different Role of Biotransformation in the Elimination of Some Important Pharmaceuticals and Industrial Xenobiotics.- The Effect of Heavy Metals (Lead, Manganese, Mercury) on the Concentration of Free Amino Acids in the Liver of Rats.- Involvement of Phenolic Metabolites in the Irreversible Protein-Binding of 14C-Bromobenzene Catalysed by Rat Liver Microsomes.- Effect of Acute Intoxication with Some Heavy Metals on Drug Metabolism.- Single Intravenous Dose Kinetics and Accumulation of Atenolol in Patients with Impaired Renal Function and on Hemodialysis.- Hepatic Nuclear Protein Kinases in Young Rats Pretreated with 3-Methylcholanthrene.- Hepatic Nuclear Free and Engaged RNA-Polymerases in Young Rats Pretreated with 3-Methylcholanthrene.- The Role of Metabolic Factors in the Interaction Between Opiates and Homopyrimidazoles in the Central Nervous System.- Research on Pharmacokinetics During Pregnancy.- Towards Standardization of the Reconstituted Mixed Function Oxidase Systems with Cytochrome P-450.- Excretion of Nalidixic Acid via Mother’s Milk.- Effect of Insulin on the Biliary Excretion of Some Organic Anions in Rats.- Aspects of Methodology Employed in the Investigation of Combined Chemical Effects on Acute Oral Toxicity.- Modification of Toxicity of Violamycin BI (VBI) by Complex Formation with DNA, Metal Ions, and by Pretreatment with ?-Tocopherol.- Comparative Studies on Cardiotoxicity of Some Anthracycline Antitumor Antibiotics.- The Influence of Drugs on the Acute Toxicity of Cytisine.- Requirements for Toxicological Evaluation of New Pesticides in Poland and the GDR (Abstract).- Therapy of Acute Oral Poisonings by Organic Solvents: Treatment by Activated Charcoal in Combination with Laxatives.- Toxicity Evaluation of Water Soluble Substances of Dental Materials by Means of Cell Population in vitro.- Cardiotoxicity of Drugs Detected on Chicken Embryos.- The Effect of High Concentrations of Oxygen on Paraquat and Diquat Toxicity in Rats.- Planning of Experiments for the Testing of Chronic Toxicity in Rats Taking into Account Biorhythms.- Acute and Cutaneous Toxicity of ?-Chlorovinyl Ketones and Aldehydes in Rodents.- Cardiotoxicity from Orphenadrine Intoxications in Humans.- Morphological and Biochemical Criteria for Evaluating Cytotoxic Effects of Antiviral Substances.- Toxicological Effects of Steam-Sterilized High Lactose Diets on Conventional and Gnotobiotic Rats.- Effects on Mice of Numbers of Animals per Cage: An 18-Month Study (Preliminary Results).- Toxicological Tests on the Safety of Fermosin for Pigs, a Novel Microbial Feed from Petroleum Distillate.- Nutritional Toxicological Studies with Lannate: Interactions with Caffeine and Ethanol.- The Occurrence of Carcinogenic Polycyclic Hydrocarbons in Foodstuffs in Hungary.- An Evaluation of the Toxicity of Thiuram in Combination with other Pesticides.- Testicular Atrophy Produced by Phthalate Esters.- Different Pituitary Prolactin Cell-Stimulating Effects of Various Estrogens in Female Rats.- Changes in the Gonads, Reproduction and Generations of White Rats Under the Effect of Some Pesticides.- Clofibrate and the Development of Rats.- Drug-Induced Histological Changes in Rat Seminiferous Tubular Epithelium.- The Influence of Haloperidol Pretreatment on the Morphine Toxicity.- Neurochemical Alterations in Rat Brain as a Test for Studying the Neurotoxicity of Organophosphorus Insecticides.- Effects of Preceding Sensibilization by Reserpine and Haloperidol on Toxicity of Dopaminergic Agonists.- The Use of Radionuclides for Evaluation of Dermal Irritation with Drugs (Abstract).- Influence of Gold Salts on the Content of Trace Elements in Serum of Patients with Rheumatoid Arthritis Under Sanocrysin Treatment.- The Influence of Acetylsalicylic Acid, Phenylbutazone, Indomethacin and Flufenamic Acid on the Kinetics of Leukocytes During Acute Inflammation.- Influence of Liver Enzyme Induction Caused by Diphenylhydantoin and Diazepam on Bone Mass of Rats.- Author Index.