From Gene to Therapy: Understanding Human Disease through Genetics

ISBN-13: 9781615047529 / Angielski / Miękka / 2017 / 89 str.

Michael Dean

Opis

Provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases are provided, drawing on the author's research.

Spis treści

• Introduction
• Cystic Fibrosis: From Family Studies to Gene Mapping, Cloning, and Function to Therapy
• Cancer Genetics and Developmental Biology
• Chromosome Alterations and Cancer (MYC)
• Discovery of an AIDS Resistance Gene and Development of a Targeted Therapy (CCR5)
• Cancer in a Petri Dish: Discovery of an Oncogene (MET)
• Studying Populations of Cancer Patients
• From Cancer Virus to Cancer Vaccine: HPV and Cervical Cancer
• Sequencing the Tumor Genome
• ABC Genes: A Gene Family Causing Multiple Diseases
• An Eye on Macular Degeneration and Gene Therapy
• Conclusion
• References
• Author Biography