Fragment-Based Drug Discovery and X-Ray Crystallography

ISBN-13: 9783642275395 / Angielski / Twarda / 2012 / 228 str.

Marko Hyv Nen; Thomas Davies

Opis

Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. TickleHsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. HubbardCombining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors, by Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu and Andrew W. StamfordCombining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery, by Michael Hennig, Armin Ruf and Walter HuberTargeting Protein Protein Interactions and Fragment-Based Drug Discovery, by Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive and Marko HyvonenFragment Screening and HIV Therapeutics, by Joseph D. Bauman, Disha Patel and Eddy ArnoldFragment-Based Approaches and Computer-Aided Drug Discovery, by Didier Rognan"

Spis treści

D. A. Erlanson
Introduction to Fragment-Based Drug Discovery.-

T. G. Davies
Ian J. Tickle
Fragment Screening Using X-Ray Crystallography.-

S. Roughley
L. Wright
P. Brough
A. Massey
R. E. Hubbard
Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening.-

D. F. Wyss
Y.-S. Wang
H. L. Eaton
C. Strickland
J.s H. Voigt
Z. Zhu
A. W. Stamford
Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors.-

M. Hennig
A. Ruf
Walter HuberCombining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery.-

E. Valkov
T. Sharpe
M. Marsh
Sa. Greive
M. Hyvönen
Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery.-

J.h D. Bauman
D. Patel
E. Arnold
Fragment Screening and HIV Therapeutics.-

D. Rognan
Fragment-Based Approaches and Computer-Aided Drug Discovery.