Fortschritte Der Chemie Organischer Naturstoffe Progress in the Chemistry of Organic Natural Products

ISBN-13: 9783709173497 / Angielski / Miękka / 2012 / 307 str.

A. Cave; D. Cortes; B. Figadere

Opis

The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Spis treści

The Dolastatins.- 1. Introduction.- 2. Dolabella auricularia.- 3. Isolation and Structure Determination of the Dolastatins.- 4. Synthesis of the Dolastatins.- 4.1 Dolastatin 3.- 4.2 Dolastatin 10.- 4.2.1 Dolaphenine (Doe).- 4.2.2 Dolaproine (Dap).- 4.2.3 Dolaisoleuine (Dil).- 4.2.4 Dolaproinyl-Dolaphenine (Dap-Doe).- 4.2.5 Conversion of Dap-Doe to Dolastatin 10.- 4.2.6 Chromatography of Dolastatin 10.- 4.2.7 High-Field NMR Analysis of Dolastatin 10.- 4.3 Syntheses of (6R)-Isodolastatin 10 and Other Chiral modifications of Dolastatin 10.- 4.3.1 Crystal Structure of (6R)-Isodolastatin 10.- 4.3.2 Molecular Modeling of (6R)-Isodolastatin 10.- 4.4 Structural Modifications of Dolastatin 10.- 4.5 Synthesis of Dolastatin 15.- 4.6 Synthesis of Dolastatin C.- 5. Spectral and Analytical Characterization.- 5.1 Dolastatin 10.- 5.2 Dolastatins 11 and 12.- 5.3 Dolastatin 13.- 5.4 Dolastatin 14.- 5.5 Dolastatin 15.- 6. Cytostatic and Antineoplastic Activities.- 6.1 Dolastatins 10-15.- 6.2 Dolastatin 10 Structural Modifications.- 6.2.1 Chiral Isomers.- 6.2.2 Structural Substitutions.- 7. Biochemical Mechanisms of Action.- 7.1 Inhibition of Tubulin Assembly and Mitosis.- 7.2 Effects on Actin.- 8. Pharmacology and Toxicology.- 9. Conclusion.- Acknowledgements.- References.- Acetogenins from Annonaceae.- I. Introduction.- II. Classification.- Synonyms of Acetogenins.- Listing (Structures and Physical Data).- Distribution.- III. Extraction and Isolation.- IV. Structure Elucidation.- V. Biogenetic Hypotheses.- VI. Syntheses.- VII. Biological Activities.- Acknowledgements.- References.- Author Index.