Folate in Health and Disease

ISBN-13: 9781420071245 / Angielski / Twarda / 2009 / 602 str.

Lynn B. Bailey

Opis

During the fifteen years since the bestselling first edition of Folate in Health and Disease was published, there have been thousands of new research studies related to folate and its role in health and disease. The second edition of the book uniquely bridges the gap between basic science and public health/clinical medicine. Presents Groundbreaking Findings on Folate s Role in Health
New insights related to folate chemistry, bioavailability, kinetics, metabolism, nutrient-gene, and nutrient-nutrient interaction are coupled with a public health/clinical medicine perspective of research findings targeted to birth defects, vascular and neurological diseases, and cancer. Epidemiological evidence is interpreted in tandem with new findings related to folate s mechanistic role in health maintenance and disease/birth defect prevention. Global recommendations for folate intake and a synopsis of folic acid fortification programs are featured. Folate acid intake and status in the U.S. are described in relation to the impact of fortification. A comprehensive critique of analytical techniques for folate analysis provides a valuable resource for future investigations as well as an interpretation of existing studies. Contributions from 50+ International Experts
This authoritative text covers:

• Folate-related genetic polymorphisms and birth defect risk
• Folic acid fortification programs and effects on NTDs
• Vitamin B12 and choline interactions with folate
• Alcohol s influence on folate status and methionine metabolism
• Clinical folate deficiency and assessment
• Folate intake recommendations globally; consumption and status in the U.S.

Assembling more than 50 international experts working on the front lines of folate research, this standard-setting reference brings you up to speed on the explosion of information garnered from a wealth of new developments. It continues to be a must-have resource for investigators in both basic and applied research and scientists and nutritionists in academia, clinical medicine, and public health. "

Keeping up with the explosion in information garnered from a wealth of new research, this volume provides an up-to-date resource on new areas of clinical interest related to folate metabolism. Such areas include the role of folate in birth defects, cancer, cardiovascular disease, and neural tube defects. This edition includes new material relating folate to neurological function as well as a chapter on folate-gene interactions. Of direct use to clinicians, the book presents the latest research on folate intake and discusses dietary recommendations for health maintenance and disease prevention. It includes estimates of dietary folate intake for the US population and specific population subgroups.