Epithelial Transport Physiology

ISBN-13: 9781627038430 / Angielski / Miękka / 2014 / 488 str.

George a Gerencser

Opis

Biological cell membranes regulate the transfer of matter and information between the intracellular and extracellular compartments as basic survival and maintenance functions for an organism. This volume contains a series of reviews that are c- cerned with how epithelial plasma membranes regulate the transport of solutes between the intracellular and extracellular compartments of a cell. This book is also an attempt to analyze the molecular basis for the movement of various solutes across an epithelial cell membrane. This volume is devoted to a diversity of epithelial transport mechanisms in rep- sentative cell membranes of a variety of living things. The ?rst section of the book (Chapters 1-6) focuses on mechanisms of solute transport in epithelia of inver- brates. The last section which comprises ten chapters (Chapters 7-16) deals with solute transporters in epithelial cell membranes of vertebrates. It is hoped that with this particular ordering the reader can glean a telescopic view of the evolutionary history of the various epithelial solute transporters.

Recenzje

From the reviews:

"Gerencser calls attention to the universality of transport protein functions across invertebrate and vertebrate taxa in Epithelial Transport Physiology. ... this volume will be a resource for researchers who require working knowledge of the transporters and processes that have been covered. This textbook has the potential to enhance graduate-level classes with permissively extensive curricula. Without doubt, the transcendental view of transport physiology that Gerencser has presented will appeal to the curiosity of erudite physiologists and this volume will be a valuable addition to their collections." (Jason R. Rock, The Quarterly Review of Biology, Vol. 86 (4), December, 2011)

Spis treści

Table of Contents: 1. Gerencser, George A. - University of Florida a. Active, electrogenic chloride absorption in invertebrate foregut. b. Sulfate transport in lobster hepatopancreas 2. Ahearn, Gregory A. – University of North Florida a. Heavy metal transport in lobster lysosomes 3. Harvey, William R. – University of Florida and Temple University a. H+-ATPase and K+ /H + antiporter constitute a K+ pump in lepidopteran midgut b. Genomic regulation of amino acid transport 4. Hanrahan, John W. – McGill University a. CFTR, a transporter in health and disease 5. White, John F. – Emory University a. Chloride transport in the vertebrate intestine 6. Markovich, Daniel – University of Queensland a. Sulfate and phosphate transport in intestinal and renal epithelia 7. Stevens, Bruce R. – University of Florida a. Amino acid transporters in mammalian epithelia 8. Cheeseman, Christopher – University of Edmonton a. Sugar transport in vertebrate epithelia 9. Weiner, David – University of Florida a. Renal acid/base regulation via ammonia transport in mammals 10. Wingo, Charles – University of Florida a. Renal acid/base control: K+ /H +-ATPase contribution

Blurb

The general theme of Epithelial Transport Physiology is epithelial transport of molecules and ions, which includes the regulation of these mechanisms either directly, through secondary messengers, or via nuclear commands.  Biologic transport of ions and, or, molecules across epithelial bio-membranes are mediated by proteins or protein-based molecules.  Over the past forty to forty-five years, the primary structures of many of these proteins have been elucidated.  One of the universalities that has emerged during this investigative process is the commonality of function amongst epithelial transporters up and down the phylogenetic tree of animals.  The central subject of Epithelial Transport Physiology is to provide a comprehensive, contemporary review of epithelial transport and the responsible transporter proteins, while elucidating the wide spectrum of new methods examining epithelial transporters such as patch clamping, reconstitution, molecular biology and molecular physiology that are now available for the application to epithelial plasma membrane systems.

Contributors to this volume were chosen by the editor, George A. Gerencser, and were selected for their outstanding accomplishments in the field, and for their clarity and breadth of presentation.  Epithelial Transport Physiology is directed to both basic and clinical scientists working in membrane transport and related areas, to graduate students and advanced undergraduates seeking a broad purview of the subject, and to other investigators and potential investigators seeking a vista of the new frontiers of molecular epithelial transporters.