Epigenetics and Proteomics of Leukemia: A Synergy of Experimental Biology and Computational Informatics

ISBN-13: 9783030687106 / Angielski / Miękka / 2022

R¯uta Navakauskien˙e;Dalius Navakauskas;Veronika Borutinskait˙e

Opis

This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy.Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.

Spis treści

Overview / Introduction

Section I: Epigenetics in Leukemia

Chapter 1: Genetic and Epigenetic Alterations in Leukemia

Chapter 2: Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment

Chapter 3: Chromatin Remodeling during Leukemia Cell Proliferation and Differentiation

DNA Methylation and Epigenetic Regulation

Chromatin Functional Regulation by Histone Modification

Chapter 4: Approaches to Epigenetic Treatment of Leukemia

Section II: Proteomics in Leukemia

Chapter 5: Proteome in Leukemic vs. Differentiated Leukemia Cells

Chapter 6: Protein Phosphorylation in Leukemia

Chapter 7: Computational Methods for Proteome Analysis

2DE Fractionation and Visualization

Proteomic Data Processing

Proteomic Data Analysis

Image Acquisition and Data Analysis

Section III: Protein Localization in Leukemia

Chapter 8: Protein Translocation into the Nucleus during Leukemia Cell Differentiation

Chapter 9: Protein Visualization in Leukemic Cells

Chapter 10: Computational Methods for Protein Localization Estimation

Fluorescent Image Processing

Fluorescent Image Acquisition and Analysis

Section IV: Future Therapy in Leukemia

O autorze

Rūta NAVAKAUSKIENĖ, Dr. Prof.

Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Sauletekio av. 7, LT-10257 Vilnius, Lithuania

Dalius NAVAKAUSKAS, Dr. Prof.

Department of Electronic Systems, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko st. 41-426, LT-03227 Vilnius, Lithuania

Veronika BORUTINSKAITĖ, Dr.

Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Sauletekio av. 7, LT-10257 Vilnius, Lithuania

Dalius MATUZEVIČIUS, Dr. Assoc. Prof.

Department of Electronic Systems, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko st. 41-413, LT-03227 Vilnius, Lithuania