Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging

ISBN-13: 9780443134920 / Angielski

Albert Stuart Reece; Gary Kenneth Hulse

Opis

Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging provides a novel and comprehensive exploration of four areas that have previously been associated with cannabis use, namely mental health in adults and young adults, pediatric autism, congenital anomalies, and pediatric cancers, including testicular cancer, and explores the possibility of how these associations might be reflected in overall disease trends at the population health level. This book surveys these four areas in detail and applies cutting-edge analytical software and geospatial space–time analytical techniques to these questions. It makes new and novel observations using advanced geostatistical techniques and their formal techniques of causal inference. The impact of the work is greatly amplified by the inclusion of detailed cellular and molecular mechanistic pathways exploring some of the mechanistic bases that are likely to underpin the megatrends observed at the population health level. It also explores the impacts on brain development and the epigenetic footprint, which are likely to have a multigenerational impact. Such findings greatly expand the impact and parameters of the present cannabis debate. With all this information gathered into one book in an easily readable form, Epidemiology of Cannabis is a reference for clinicians, health science and allied health practitioners, public health and basic science researchers as well as drug and health regulators interested in these topics. It is also suitable for inclusion in course work and study preparation courses at both the undergraduate and postgraduate levels.

Spis treści

SECTION 1: Mental Illness Close Parallels between Cannabis Use and Deteriorating US Mental Health at Four Levels Supports and Extends the Epidemiological Salience of Demonstrated Causal Mental Health Relationships: A Geospatiotemporal Study 1. National Trends 2. Regional Trends 3. State Trends 4. Sub-State Trends 5. Geospatial Analysis 6. Causality Criteria SECTION 2: Autistic Spectrum Disorder Linked Rise of Cannabis Use and Autism Incidence Demonstrated by Close Three Level Geospatiotemporal Relationships, USA, 1990-2011. 7. National Trends 8. Regional Trends 9. State Trends 10. Geospatial Analysis 11. Changes in State Trends 12. Legal Status and Autism 13. Geospatial Analysis of Legal Status and Autism SECTION 3: Congenital Anomalies Geotemporospatial Analysis of United States 38-44 Congenital Anomalies as a Function of Multiple Cannabinoid- and Substance- Exposure in the Decades of Cannabis Legalization: Phenocopying Thalidomide and Hundred Megabase-Scale Genotoxicity 14. Drug Use by Race 15. Drugs and Defects Overview 16. Chromosomal Anomalies: Anomalies 1:5 17. Gastroschisis: Anomaly 6 18. Atrial Septal Defect (Secundum): Anomaly 7 19. Cardiovascular Defects of Interest: Anomalies 8-11 20. Hawaiian - American Review: Anomalies 12-37 21. Conclusion: Time Course, Quintile Analysis, Canada, Thalidomide, Legal Status, Causality SECTION 4: Cancer and Heritable Cancer Reflections of Heritable Cannabis-Related Genotoxicity in Rising Adult and Pediatric Cancer Rates Across USA in Time- and Ethnicity- Denominated Analyses 22. General Introduction and Overview 23. Sequential Analysis of Cancer Types 24. Geospatiotemporal Modelling - Fitted Values 25. Geospatiotemporal Modelling - Matrix Multiplication 26. Summary of Geospatiotemporal Modelling 27. Overall Conclusions SECTION 5: Epigenetics and Aging As modern epigenetic studies provide profound insights into the observed pattern of teratological, cancerogenic and age-accelerated disease it becomes important to consider new findings in detail. 28. Epigenetics of Cannabinoids - Introduction 29. Epigenetics of Cannabinoids - Historical Studies 30. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Overview 31. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Stem Cells 32. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Chromosomes 33. Epigenetics of Cannabinoids - Longitudinal Sperm Teratology - Brain 34. Epigenetics of Cannabinoids - Longitudinal Sperm Teratology - Cardiovasculature 35. Epigenetics of Cannabinoids - Longitudinal Sperm Teratology - Other Organs 36. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Carcinogenesis 37. Epigenetics of Cannabinoids - Accelerated Aging