Enzymology and Molecular Biology of Carbonyl Metabolism 7

ISBN-13: 9781461371465 / Angielski / Miękka / 2012 / 555 str.

Henry Weiner; Edmund Maser; David W. Crabb

Opis

Prior to the start of the eighth meeting, I had the good sense to ask Professor Rosa Angela Canuto of Turin, Italy if she would help me organize the ninth meeting. She quickly suggested that both she and Dr. Guiliana Muzio, also of Turin, help plan the meet- ing. Each of our previous eight meetings was a unique experience for the participants. The science was always outstanding and the presentations and discussions were excellent. By moving each meeting to a different part of the world we were able to experience exciting foods and cultural aspects of the world in addition to the science. The ninth meeting was no exception. We met from June 18 to 22 in the small mountain city of Varallo, Italy, the birth place of Dr. Canuto. Holding the scientific sessions in a several-hundred-year-old converted mansion and having an afternoon trip to either Lago Maggiore or Monte Rosa made some aspects of this meeting extremely memorable. An additional unique aspect of the social portion of the meeting was our ability to invite the townspeople to share with us a concert performed in an old church. Though the social and cultural aspects of the meeting were outstanding, the pur- pose of the meeting was to exchange scientific information about the status of the three enzyme systems.

Spis treści

Aldehyde Dehydrogenasé.- 1. The Big Book of Aldehyde Dehydrogenase Sequences: An Overview of the Extended Family.- 2. Reaction-Chemistry-Directed Sequence Alignment of Aldehyde Dehydrogenases.- 3. Three-Dimensional Structure of Mitochondrial Aldehyde Dehydrogenase: Mechanistic Implications.- 4. A Structural Explanation for the Retinal Specificity of Class 1 ALDH Enzymes.- 5. Structure and Function of Betaine Aldehyde Dehydrogenase: An Enzyme within the Multienzyme Aldehyde Dehydrogenase System.- 6. Evaluation of the Roles of the Conserved Residues of Aldehyde Dehydrogenase.- 7. Aldehyde Dehydrogenase Catalytic Mechanism: A Proposal.- 8. Inhibition of Human Mitochondrial Aldehyde Dehydrogenase by Metabolites of Disulfiram and Structural Characterization of the Enzyme Adduct by HPLC-Tandem Mass Spectrometry.- 9. Mechanism of Inhibition of Rat Liver Class 2 ALDH by 4-Hydroxynonenal.- 10. Aldehyde Inhibitors of Aldehyde Dehydrogenases.- 11. Covalent Modification of Sheep Liver Cytosolic Aldehyde Dehydrogenase by the Oxidative Addition of Coloured Phenoxazine, Phenothiazine and Phenazine Derivatives.- 12. A Thioester Analogue of an Amino Acetylenic Aldehyde Is a Suicide Inhibitor of Aldehyde Dehydrogenase and an Inducer of Apoptosis in Mouse Lymphoid Cells Overexpressing the bcl2 Gene.- 13. Reaction between Sheep Liver Mitochondrial Aldehyde Dehydrogenase and a Chromogenic ‘Reporter Group’ Reagent.- 14. Activity of the Human Aldehyde Dehydrogenase 2 Promoter Is Influenced by the Balance between Activation by Hepatocyte Nuclear Factor 4 and Repression by Perosixome Proliferator Activated Receptor ?, Chicken Ovalbumin Upstream Promoter-Transcription Factor, and Apolipoprotein Regulatory Protein-1.- 15. a,?-Unsaturated Aldehydes Mediate Inducible Expression of Glutathione S-Transferase in Hepatoma Cells through Activation of the Antioxidant Response Element (ARE).- 16. Effect of Arachidonic Acid Alone or with Prooxidant on Aldehyde Dehydrogenases in Hepatoma Cells.- 17. Prepubertal Regulation of the Rat Dioxin-Inducible Aldehyde Dehydrogenase (ALDH3).- 18. Effects of Tamoxifen and Toremifene on ALDH1 and ALDH3 in Human Retinal Pigment Epithelial Cells and Rat Liver.- 19. Negative Regulation of Rat Hepatic Aldehyde Dehydrogenase 3 by Glucocorticoids.- 20. Modulation of Class 3 Aldehyde Dehydrogenase Gene Expression: An Eye Opening Experience.- 21. Susceptibility of Hepatoma Cells to Lipid Peroxidation and Adaptation of ALDH 3C Activity to Iron-Induced Oxidative Stress.- 22. The Lack of AHD4 Induction by TCDD in Corneal Cells May Involve Tissue-Specific Regulatory Proteins.- 23. Human Corneal and Lens Aldehyde Dehydrogenases: Localization and Function(s) of Ocular ALDH 1 and ALDH3 Isozymes.- 24. The Role of Retinoid Metabolism by Alcohol and Aldehyde Dehydrogenases in Differentiation of Cultured Neuronal Cells.- 25. Metabolism of Retinaldehyde by Human Liver and Kidney.- 26. The Hunt for a Retinal-Specific Aldehyde Dehydrogenase in Sheep Liver.- 27. Cardiac Metabolism of Enals.- 28. Oxidation of Ethanol to Acetaldehyde in Brain and the Possible Behavioral Consequences.- 29. Cloning and Expression of a cDNA Encoding a Constitutively Expressed Rat Liver Cytosolic Aldehyde Dehydrogenase.- 30. The Roles of Acetaldehyde Dehydrogenases in Saccharomyces Cerevisiae.- 31. Characterization of an Aldehyde Dehydrogenase Gene Fragment from Mung Bean (Vigna radiatd) Using the Polymerase Chain Reaction.- 32. Aldehyde Dehydrogenase Gene Superfamily: The 1998 Update.- Alcohol Dehydrogenase.- 33. Human Alcohol Dehydrogenase Family: Functional Classification, Ethanol/Retinol Metabolism, and Medical Implications.- 34. Dynamics in Alcohol Dehydrogenase Elucidated from Crystallographic Investigations.- 35. Studies on Variants of Alcohol Dehydrogenases and Its Domains.- 36. Uncompetitive Inhibitors of Alcohol Dehydrogenases.- 37. Tandem Mass Spectrometry of Alcohol Dehydrogenase and Related Biomolecules.- 38. Function of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Gene Families in Retinoid Signaling.- 39. Primary Role of Alcohol Dehydrogenase Pathway in Acute Ethanol-Induced Impairment of Protein Kinase C-Dependent Signaling System.- 40. Class II Alcohol Dehydrogenase: A Suggested Function in Aldehyde Reduction.- 41. Zinc Binding Characteristics of the Synthetic Peptide Corresponding to the Structural Zinc Site of Horse Liver Alcohol Dehydrogenase.- 42. Amphibian Alcohol Dehydrogenase: Purification and Characterization of Classes I and III from Rana perezi.- 43. Extracellular Acidification: A Novel Detection System for Ligand/Receptor Interactions: Demonstration with Bioactive Peptides and CHO or Pancreatic ? Cells, but of Possible Interest for Tracing Putative Receptors in Ethanol Metabolism.- Short and Medium Chain Dehydrogenase.- 44. Multiplicity and Complexity of SDR and MDR Enzymes.- 45. Regulatory Factors and Motifs in SDR Enzymes.- 46. Bioinformatics in Studies of SDR and MDR Enzymes.- 47. The Protective Role of 11 ?-Hydroxysteroid Dehydrogenase/Carbonyl Reductase against Tobacco-Smoke Related Lung Cancer.- 48. Structure-Function Relationships of 3 ?-Hydroxysteroid Dehydrogenases Involved in Bile Acid Metabolism.- 49. Cloning and Sequencing of a New Comamonas testosteroni Gene Encoding 3?-Hydroxysteroid Dehydrogenase/Carbonyl Reductase.- 50. Comparative Properties of Three Pteridine Reductases.- 51. Effect of Androgen Structures on the Inhibition of Metyraponeinreductase in Rat, Mouse, and Human Liver.- Reductases.- 52. Physiological Relevance of Aldehyde Reductase and Aldose Reductase Gene Expression.- 53. The Aldo-Keto Reductases and Their Role in Cancer.- 54. Structure-Function Studies of FR-1: A Growth Factor-Inducible Aldo-Keto Reductase.- 55. 4-Hydroxynonenal Metabolism by Aldo/Keto Reductase in Hepatoma Cells.- 56. Interconversion Pathways of Aldose Reductase Induced by Thiol Compounds.- 57. Aldo-Keto Reductases in Norepinephrine Metabolism.- 58. Rotamers of Tolrestat and Their Binding Mode to Aldose Reductase.- 59. Stereoselective High-Affinity Reduction of Ketonic Nortriptyline Metabolites and of Ketotifen by Aldo-Keto Reductases from Human Liver.- 60. Formation of Lens Aldose Reductase Mixed Disulfides with GSH by UV Irradiation and Its Proteolysis by Lens Calpain.- 61. Inhibition of Aldose Reductase by Gossypol and Gossypol-Related Compounds.- 62. Inhibition of Human Aldose and Aldehyde Reductases by Non-Steroidal Anti-Inflammatory Drugs.- 63. Regulation of Aldose Reductase by Aldehydes and Nitric Oxide.- 64. The Cytotoxicity of Methylglyoxal and 3-Deoxyglucosone Is Decreased in the Aldehyde Reductase Gene-Transfected Cells.- 65. Enzymes Metabolizing Aldehydes in HL-60 Human Leukemic Cells.- 66. Rat Carbonyl Reductase: How Many Genes?.- 67. Cytostatic Drug Resistance: Role of Phase-I Daunorubicin Metabolism in Cancer Cells.- 68. Expression of mRNAs for Dihydrodiol Dehydrogenase Isoforms in Human Tissues.- 69. Alterations in the Expression of Daunorubicin Phase-I Metabolising Enzymes in Different Carcinoma Cell Lines.