Engineered Carbohydrate-Based Materials for Biomedical Applications: Polymers, Surfaces, Dendrimers, Nanoparticles, and Hydrogels

ISBN-13: 9780470472354 / Angielski / Twarda / 2011 / 416 str.

Ravin Narain

Opis

This book addresses the need for a comprehensive book on the design, synthesis, and characterization of synthetic carbohydrate-based polymeric materials along with their biological applications. The first two chapters cover the synthesis and self-assembly of glycopolymers and different techniques for creating these synthetic polymers. Subsequent chapters account for the preparation of block copolymers, branched glycopolymers, glycosurfaces, glycodendrimers, cationic glycopolymers, bioconjugates, glyconanoparticles and hydrogels. While these chapters comprehensively review the synthetic and characterization methods of those carbohydrate-based materials, their biological applications are discussed in detail.

Spis treści

PREFACE.

CONTRIBUTORS.

1 SYNTHESIS OF GLYCOPOLYMERS (Samuel Pearson, Gaojian Chen, and Martina H. Stenzel).

2 BLOCK GLYCOPOLYMERS AND THEIR SELF–ASSEMBLY PROPERTIES (Qian Yang).

3 CATIONIC GLYCOPOLYMERS (Marya Ahmed and Ravin Narain).

4 GLYCOPOLYMER BIOCONJUGATES (Marya Ahmed and Ravin Narain).

5 GLYCOPOLYMER–FUNCTIONALIZED CARBON NANOTUBES (Marya Ahmed and Ravin Narain).

6 GLYCONANOPARTICLES: NEW NANOMATERIALS FOR BIOLOGICAL APPLICATIONS (Isabel Garc a, Juan Gallo, Marco Marradi, and Soledad Penades).

7 GLYCODENDRIMERS AND THEIR BIOLOGICAL APPLICATIONS (Elizabeth R. Gillies).

8 GLYCOSURFACES (Anca Mateescu and Maria Vamvakaki).

9 CARBOHYDRATE–DERIVED HYDROGELS AND MICROGELS (Mitsuhiro Ebara).

10 MODIFIED NATURAL POLYSACCHARIDES AS NANOPARTICULATE DRUG DELIVERY DEVICES (Archana Bhaw–Luximon).

INDEX.

O autorze

RAVIN NARAIN, PhD, is an Associate Professor at the University of Alberta and an Associate Investigator of the Alberta Ingenuity Centre for Carbohydrate Science (AICCS) in Alberta, Canada. His research is focused on the development of new polymeric and nanomaterials for biomedical applications, and he has published more than forty–five peer–reviewed papers. Dr. Narain is also a reviewer for more than sixteen journals, including Journal of Polymer Science Part A: Polymer Chemistry (Wiley), Journal of the American Chemical Society, Biomacromolecules, Macromolecules, Chemistry of Materials, Langmuir, Bioconjugate Chemistry, ACS Nano, Nanoletters, Nano Today, Chemical Communications, and Soft Matter.

Blurb

The definitive guide to the synthesis and applications of biomaterials

While carbohydrate–based materials are commonly used in numerous biomedical and biological applications, there is a paucity of systematic information on how best to approach the design, synthesis, and characterization of such materials. This book provides a much–needed overview of the subject, focusing on synthesis and characterization techniques for several key biomaterials, including polymers, surfaces, dendrimers, nanoparticles, and hydrogels.

Featuring contributed chapters written by experts in the field, this volume offers practical guidance on how to choose the appropriate synthetic approach for each material under discussion, clearly explaining their interactions with living organisms, their role in various biological processes, and their biomedical or biological applications. Coverage includes:

• Synthesis and self–assembly of glycopolymers biomaterials and their role in tissue engineering, drug delivery, and non–invasive gene therapy

• The role of glycopolymer bioconjugates in biological assays, diagnostics, and the study of carbohydrate–protein–based interactions

• The design and synthesis of biomacromolecules, including glycodendrimers, nanoparticles, and hydrogels

• Biological and biomedical applications of nanoparticles in drug delivery devices, pathogen inhibition, fluorescence problems, magnetic resonance imaging, and others

• Hydrogel applications in tissue engineering, pathogen inhibition, and drug delivery

Engineered Carbohydrate–Based Materials for Biomedical Applications is a handy reference for polymer and materials scientists, as well as organic and carbohydrate chemists, biomedical engineers, or anyone who would like to explore the state of the art of carbohydrate–based biomaterials.