Endocrine and Hormonal Toxicology

ISBN-13: 9780471970866 / Angielski / Twarda / 1999 / 600 str.

Philip W. Harvey;Harvey; Andrew Cockburn

Opis

This text covers all types of toxicology involving the classical endocrine system, namely direct, secondary and indirect responses, and is designed to be a definitive reference in the area. A novel theme of the book is to examine hormonal mechanisms in toxicology which takes the book away from the usual approach, namely the glands as target organs. Each chapter focuses on the principle laboratory species (rodent, dog, primate) with reference as appropriate to humans. Chapters also consider, where applicable, gender and age related effects and have a standardized structure with brief introductory anatomy and physiology, followed by pharmacology, toxicology and pathology as relevant.

Recenzje

"section III of this book is a classic" (Clinical Endocrinology, No.53 2000)

Spis treści

Section 1: An Integrated Approach to Endocrine and Hormonal Toxicology

Section 2: Endocrine Organs as Toxicological Targets

Section 3: Endocrine and Hormonal Toxicology: A Target System Approach

Section 4: Endocrine Toxicology: Human and Environmental Health Perspectives

Blurb

Endocrine and Hormonal Toxicology Edited by Philip W. Harvey, Kevin C. Rush and Andrew Cockburn AgrEvo UK Ltd, Saffron Walden, UK This is the first book to consider the integrated role of the classical endocrine system and hormones (including those from tissues outside the classical endocrine system) in toxicological responses. Although focusing on the latest knowledge on endocrine glands as target organs and the mechanistic and molecular basis for toxicity in these organs, Endocrine and Hormonal Toxicology has been written to cover toxicological responses at the whole body level mediated by endocrine or hormonal mechanisms. This whole body, multi–organ approach significantly broadens the relevance of this volume to toxicologists. Following an introductory section on the types of endocrine toxicity including primary, secondary and indirect mechanisms, the next section deals with endocrine organs as toxicological targets. International contributions focus on the pituitary, thyroid and parathyroids, adrenals, testes, ovaries and the pancreas, and comparative endocrine carcinogenesis. A third section of the book develops the whole body approach, in which chapters are devoted to hormonal mechanisms of toxicity to the immune, nervous, cardiovascular, gastrointestinal and reproductive systems, as well as to the liver, kidney and skin. The final section covers human and environmental health perspectives discussing endocrine disrupting chemicals, hormonal mechanisms in breast cancer and current regulatory trends in endocrine and hormonal toxicology. The comprehensive nature of Endocrine and Hormonal Toxicology makes it accessible to both specialist and general toxicologists, and to those within the fields of endocrinology, pharmacology and pathology.