Endocrine Disruption and Human Health

ISBN-13: 9780128011393 / Angielski / Twarda / 2015 / 390 str.

Darbre, Philippa D.

Opis

Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students.

• Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health
• Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health
• Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

Recenzje

"...a comprehensive resource for toxicology students and practitioners...the first book that specifically focuses in detail on endocrine disruption and its related human health issues. Score: 96 - 4 Stars" --Doody's

Spis treści

SECTION 1 - OVERVIEW and SCOPE 1. What is endocrine disruption? 2. Which chemicals are endocrine disruptors? SECTION 2 - MECHANISMS and ASSAY SYSTEMS 3. Environmental oestrogens: disrupters of oestrogen action  4. Disrupters of androgen action  5. Assay systems for studying endocrine disruption  6. Non-monotonic responses in endocrine disruption  7. Endocrine disrupters as modifiers of endogenous hormone synthesis SECTION 3 - CONCERNS FOR HUMAN HEALTH 8. Endocrine disruption and female reproductive health  9. Endocrine disruption and breast cancer  10. Endocrine disruption and male reproductive health  11. Endocrine disruption and prostate cancer 12. Endocrine disruption and thyroid disease 13. Endocrine disruption of adrenal function  14. Endocrine disruption of developmental pathways and children's health 15. Endocrine disruption of immune function 16. Endocrine disruption and obesity, metabolic syndrome and type 2 diabetes 17. Endocrine disruption and cardiovascular disease 18. Transgenerational effects of endocrine disruption 19. Regulatory considerations

O autorze

Professor Philippa Darbre is Professor Emeritus in Oncology in the School of Biological Sciences at the University of Reading in the UK. She is an academic scientist who has been carrying out research into estrogen action in breast cancer for over 40 years and has been investigating the role of estrogen-mimicking chemicals since before the term "endocrine disruption” came into being in the early 1990s. She trained as a biochemist and holds the degrees of BScHons from the University of Birmingham, UK (1973) and PhD from the University of Cambridge, UK (1977). Her postdoctoral research began at the Molecular Medicine Institute at the University of Oxford where she held the first Nuffield Medical Research Fellowship of the University of Oxford and a Junior Research Fellowship at St Hugh's College. In 1981, she moved to the Imperial Cancer Research Fund laboratories in central London (now Cancer Research UK) where she became Head of the Cellular Endocrinology Laboratory. In 1991, she moved to the University of Reading and retired to Emeritus status in 2017. From retirement, she continues research into the role of endocrine disrupting chemicals in breast cancer together with some teaching of undergraduates in endocrinology and cancer. She continues to serve on the editorial board of the Journal of Applied Toxicology, is patron of the charity "Canceractive” and is a member of the science panel of the charity, BreastCancer UK. She has written two books on molecular biology methods, has guest-edited a previous journal volume on endocrine disrupters, has published 150 peer-reviewed research papers, and served as founding editor of the first edition of the book, Endocrine Disruption and Human Health.